Phenotypes associated with this allele

• Allele Symbol: Serpinf1^tm1Sjwi
• Allele Name: targeted mutation 1, Stanley J Wiegand
• Allele ID: MGI:3821612
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpinf1^tm1Sjwi/Serpinf1^tm1Sjwi	involves: C57BL/6J	MGI:3821615

Genotype
MGI:3821615

hm1

• Allelic Composition: Serpinf1^tm1Sjwi/Serpinf1^tm1Sjwi
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:141879 )

• at P21 retinal vessels show increased cellularity and more capillaries

• at P21 the mean endothelial cell density is increased compared to controls but no change in the mean pericyte density is detected

• however, by P42 only minimal differences in retinal vasculature are seen compared to controls

abnormal angiogenesis ( J:141879 )

• at P3, P5, and P7, expansion of retinal blood vessels out from the center of the retina is faster than in controls and reduced levels of a marker for mature astrocytes are seen

• at P7 significantly more proliferating retinal vascular cells are present compared to controls

• at P10, significantly more intermediate retinal vessels are present compared to controls

• at P10 increased apoptosis is seen but by P14 apoptosis is decreased compared to controls

• increased sensitivity to hyperoxia mediated vessel loss in the retina

vision/eye

vision/eye phenotype ( J:141879 )

N • normal eye development and retinal morphology and function despite changes in the retinal vasculature

abnormal retina vasculature morphology ( J:141879 )

• at P21 retinal vessels show increased cellularity and more capillaries

• at P21 the mean endothelial cell density is increased compared to controls but no change in the mean pericyte density is detected

• however, by P42 only minimal differences in retinal vasculature are seen compared to controls