Phenotypes associated with this allele

• Allele Symbol: Zbtb7b^tm1Litt
• Allele Name: targeted mutation 1, Dan R Littman
• Allele ID: MGI:3821617
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt	involves: C57BL/6	MGI:3821711
cx2	B2m^tm1Jae/B2m^tm1Jae Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt	involves: 129S2/SvPas * C57BL/6	MGI:3821710

Genotype
MGI:3821711

ht1

• Allelic Composition: Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal double-positive T cell morphology ( J:141144 )

• a double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSA^lo-neg TCRbeta^hi) and may represent single-positive CD4⁺ thymoyctes that are redirected to a CD8⁺ T cell lineage

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• there is about a 2-fold reduction in the number of single-positive CD4⁺ cells among mature thymocytes compared to controls

• there is also a decrease in the number of CD4⁺ T cells in the periphery

increased CD8-positive, alpha-beta T cell number ( J:141144 )

• there is a greater than 20% increase in the number of single-positive CD8⁺ cells among mature thymocytes compared to controls

• there is also an increase in the number of CD8⁺ T cells in the periphery

immune system

abnormal double-positive T cell morphology ( J:141144 )

• a double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSA^lo-neg TCRbeta^hi) and may represent single-positive CD4⁺ thymoyctes that are redirected to a CD8⁺ T cell lineage

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• there is about a 2-fold reduction in the number of single-positive CD4⁺ cells among mature thymocytes compared to controls

• there is also a decrease in the number of CD4⁺ T cells in the periphery

increased CD8-positive, alpha-beta T cell number ( J:141144 )

• there is a greater than 20% increase in the number of single-positive CD8⁺ cells among mature thymocytes compared to controls

• there is also an increase in the number of CD8⁺ T cells in the periphery

increased interferon-gamma secretion ( J:141144 )

• 47% of CD4⁺ T cells produced IFN-gamma after 3 days of stimulation with anti-CD3 and anti-CD28 compared to just 5.6% of wild-type CD4⁺ T cells

Genotype
MGI:3821710

cx2

• Allelic Composition: B2m^tm1Jae/B2m^tm1Jae; Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )

• single-positive CD8⁺ cells are found among mature thymocytes compared to mice null for just the B2m locus that have no mature CD8⁺ thymocytes

abnormal double-positive T cell morphology ( J:141144 )

• an unusual double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSA^lo-neg TCRbeta^hi) and may represent single-positive CD4⁺ thymoyctes that are redirected to a CD8⁺ T cell lineage

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )

• single-positive CD8⁺ cells are found among mature thymocytes compared to mice null for just the B2m locus that have no mature CD8⁺ thymocytes

abnormal double-positive T cell morphology ( J:141144 )

• an unusual double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSA^lo-neg TCRbeta^hi) and may represent single-positive CD4⁺ thymoyctes that are redirected to a CD8⁺ T cell lineage