About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pak6tm1Amin
targeted mutation 1, Audrey Minden
MGI:3821622
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pak6tm1Amin/Pak6tm1Amin involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3821624
cx2
Pak6tm1Amin/Pak6tm1Amin
Pak5tm1Amin/Pak5tm1Amin
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3821625


Genotype
MGI:3821624
hm1
Allelic
Composition
Pak6tm1Amin/Pak6tm1Amin
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pak6tm1Amin mutation (2 available); any Pak6 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no observable phenotype




Genotype
MGI:3821625
cx2
Allelic
Composition
Pak6tm1Amin/Pak6tm1Amin
Pak5tm1Amin/Pak5tm1Amin
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pak5tm1Amin mutation (2 available); any Pak5 mutation (38 available)
Pak6tm1Amin mutation (2 available); any Pak6 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• despite locomotor deficits, mice exhibit normal balance, coordination and anxiety levels
• mice exhibit reduced learning of active avoidance behaviors in a T-maze test compared to wild-type mice
• in a T-maze mice exhibit longer avoidance time than wild-type mice
• mice perform worse than wild-type mice in a passive avoidance T-maze test and exhibit increased time to make the incorrect response compared to wild-type mice
• mice fail to exhibit an increase in locomotor activity when exposed to a novel environment
• when exposed to a male intruder, male mice initiate fewer attacks and exhibit increased latency to attack compared to wild-type mice
• however, serotonine and dopamine levels are normal
• mice exhibit reduced grip strength compared to wild-type mice
• mice exhibit reduced locomotion in new and familiar environments compared to wild-type mice

nervous system
N
• mice exhibit normal brain morphology and levels of serotonine and dopamine are normal
• neurons have smaller growth cones with reduced widths compare to wild-type growth cones and they extend along the shaft unlike growth cones
• young and old cultured neurons have fewer, shorter neurites than wild-type neurons

reproductive system
N
• mice are fertile and male mice exhibit normal testes morphology





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory