Phenotypes associated with this allele

• Allele Symbol: Omg^tm1Shmi
• Allele Name: targeted mutation 1, Sha Mi
• Allele ID: MGI:3821628
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Omg^tm1Shmi/Omg^tm1Shmi	B6.Cg-Omg^tm1Shmi	MGI:3821705
hm2	Omg^tm1Shmi/Omg^tm1Shmi	involves: 129S4/SvJae * C57BL/6	MGI:3821703

Genotype
MGI:3821705

hm1

• Allelic Composition: Omg^tm1Shmi/Omg^tm1Shmi
• Genetic Background: B6.Cg-Omg^tm1Shmi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:142129 )

N • Background Sensitivity: mice on a congenic C57BL/6 background exhibit normal recovery from spinal cord injury

Genotype
MGI:3821703

hm2

• Allelic Composition: Omg^tm1Shmi/Omg^tm1Shmi
• Genetic Background: involves: 129S4/SvJae * C57BL/6

homeostasis/metabolism

abnormal response to injury ( J:142129 )

• Background Sensitivity: mice on a mixed 129S4/SvJae C57BL/6 background initially exhibit decreased Basso Mouse Scale scores following spinal cord injury compared to wild-type mice

• Background Sensitivity: two weeks following spinal cord injury, mice on a mixed 129S4/SvJae C57BL/6 background exhibit increased Basso Mouse Scale scores compared to wild-type mice indicating improved recovery

• Background Sensitivity: following spinal cord injury, mice on a mixed 129S4/SvJae C57BL/6 background exhibit a 3-fold increase in 5-HT+ axons 0 to 2.5 mm caudal to the lesion and a 5-fold 2.5 to 5 mm caudal to the lesion compared to in wild-type mice

• Background Sensitivity: following spinal cord injury, mice on a mixed 129S4/SvJae C57BL/6 background exhibit a 2-fold increase in the number of ascending axons compared to wild-type mice

• however, regeneration of corticospinal tract axons following spinal cord injury is normal and mice exhibit normal spinal cord recovery on a congenic C57BL/6 background