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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shmt1tm1.1Stov
targeted mutation 1.1, Patrick J Stover
MGI:3821697
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shmt1tm1.1Stov/Shmt1tm1.1Stov 129S/SvEv-Shmt1tm1.1Stov MGI:3821702
hm2
 		Shmt1tm1.1Stov/Shmt1tm1.1Stov involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 MGI:3821700
ht3
 		Shmt1tm1.1Stov/Shmt1+ 129S/SvEv-Shmt1tm1.1Stov MGI:3821701


Genotype
MGI:3821702
hm1
Allelic
Composition		 Shmt1tm1.1Stov/Shmt1tm1.1Stov
Genetic
Background		 129S/SvEv-Shmt1tm1.1Stov
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1tm1.1Stov mutation (0 available); any Shmt1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:141998 )
• on a folate/choline deficient diet levels of S-adenosylmethionine are increased and levels of S-adenosylhomocysteine are decreased compared to wild-type mice on the same diet




Genotype
MGI:3821700
hm2
Allelic
Composition		 Shmt1tm1.1Stov/Shmt1tm1.1Stov
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1tm1.1Stov mutation (0 available); any Shmt1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:141998 )
• at 6 weeks of age, levels of S-adenosylmethionine are elevated 2 fold and levels of S-adenosylhomocysteine are decreased by 60%




Genotype
MGI:3821701
ht3
Allelic
Composition		 Shmt1tm1.1Stov/Shmt1+
Genetic
Background		 129S/SvEv-Shmt1tm1.1Stov
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1tm1.1Stov mutation (0 available); any Shmt1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:141998 )
• liver nuclear DNA shows increased uracil incorporation compared to wild-type and homozygous mutant mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory