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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-T23tm3Cant
targeted mutation 3, Harvey Cantor
MGI:3821721
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2-T23tm3Cant/H2-T23tm3Cant B6.129S6-H2-T23tm3Cant MGI:3822037
cx2
 		H2-T23tm3Cant/H2-T23tm3Cant
Tg(TcraTcrb)425Cbn/? 		involves: 129S6/SvEvTac * C57BL/6 MGI:3822038
cx3
 		H2-T23tm3Cant/H2-T23tm3Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/? 		involves: 129S6/SvEvTac * C57BL/6 MGI:3822041


Genotype
MGI:3822037
hm1
Allelic
Composition		 H2-T23tm3Cant/H2-T23tm3Cant
Genetic
Background		 B6.129S6-H2-T23tm3Cant
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-T23tm3Cant mutation (0 available); any H2-T23 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:142087 )
• mice fail to respond to the protective effects of pre-treatment with an encephalomyelitic peptide before EAE induction
• severe disease develops with both PLP- or MOG- induced EAE despite pre-treatment compared to controls that develop mild disease after pre-treatment with an encephalomyelitic peptide
• CD4 T cells isolated from mice in this disease model produce robust IFN-gamma and IL-17 responses when activated in the presence of MOG peptide compared to the controls that have muted responses




Genotype
MGI:3822038
cx2
Allelic
Composition		 H2-T23tm3Cant/H2-T23tm3Cant
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-T23tm3Cant mutation (0 available); any H2-T23 mutation (35 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )
• cells are resistant to CD8 T regulatory cells when co-transferred into an immunodeficient host

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )
• cells are resistant to CD8 T regulatory cells when co-transferred into an immunodeficient host




Genotype
MGI:3822041
cx3
Allelic
Composition		 H2-T23tm3Cant/H2-T23tm3Cant
Tg(Tcra2D2,Tcrb2D2)1Kuch/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-T23tm3Cant mutation (0 available); any H2-T23 mutation (35 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )
• CD4 T cells are fully resistant to suppression by CD8 T regulatory cells in vitro as measured by proliferation and IL-2 secretion

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:142087 )
• CD4 T cells are fully resistant to suppression by CD8 T regulatory cells in vitro as measured by proliferation and IL-2 secretion




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory