Phenotypes associated with this allele

• Allele Symbol: Myh11^tm2Peri
• Allele Name: targeted mutation 2, Muthu Periasamy
• Allele ID: MGI:3821724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh11^tm2Peri/Myh11^tm2Peri	involves: 129 * C57BL/6	MGI:3821732

Genotype
MGI:3821732

hm1

• Allelic Composition: Myh11^tm2Peri/Myh11^tm2Peri
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Myh11^tm2Peri/Myh11^tm2Peri mice exhibit segmental distention of alimentary tract, retention of urine in renal pelvis/bladder and development of end-stage hydronephrosis

mortality/aging

premature death ( J:142230 )

• all mice die by 4 weeks of age

postnatal lethality, incomplete penetrance ( J:142230 )

• 50% of mice die within the first two weeks and all mice die within 4 weeks of birth

muscle

abnormal sarcomere morphology ( J:142230 )

• the number of thick filaments in bladder smooth muscles cells and the cross-sectional diameter of myosin filaments are decreased compared to in wild-type mice

abnormal muscle contractility ( J:142230 )

• in response to potassium, bladder muscle strips or aortic rings from 3 to 7 day old mice exhibit increased sustained phase of maximal contraction and reduced concentration of potassium to reach 50% of maximal contraction compared to wild-type smooth muscle

• smooth muscle contraction in response to carbachol is enhanced compared to in wild-type smooth muscle

• aortic rings exhibit increased contraction in response to submaximal potassium levels compared to wild-type smooth muscle

renal/urinary system

hydronephrosis ( J:142230 )

• after 2 weeks, mice exhibit retention of urine in the renal pelvis and/or bladder and develop end-stage hydronephrosis unlike wild-type mice

distended urinary bladder ( J:142230 )

ischuria ( J:142230 )

• after 2 weeks, mice exhibit retention of urine in the renal pelvis and/or bladder

digestive/alimentary system

abnormal digestive system morphology ( J:142230 )

• after 2 weeks, mice exhibit segmental distention of the alimentary tract unlike wild-type mice

growth/size/body

decreased body weight ( J:142230 )

• by day 20 mice weigh less than wild-type mice

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:142230 )

• smooth muscle contraction in response to carbachol is enhanced compared to in wild-type smooth muscle