Phenotypes associated with this allele

• Allele Symbol: Ffar1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3821733
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ffar1^tm1Dgen/Ffar1^tm1Dgen	B6.129P2-Ffar1^tm1Dgen	MGI:3821736
hm2	Ffar1^tm1Dgen/Ffar1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3821735
hm3	Ffar1^tm1Dgen/Ffar1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6N	MGI:4818770

Genotype
MGI:3821736

hm1

• Allelic Composition: Ffar1^tm1Dgen/Ffar1^tm1Dgen
• Genetic Background: B6.129P2-Ffar1^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:141957 )

N • no abnormal metabolic parameters

Genotype
MGI:3821735

hm2

• Allelic Composition: Ffar1^tm1Dgen/Ffar1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

endocrine/exocrine glands

decreased amylin secretion ( J:141957 )

• attenuated amylin release when plasma free fatty acids become elevated

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:141957 )

N • glucose tolerance is not improved over controls regardless of diet

abnormal circulating hormone level ( J:141957 )

• attenuated amylin release when plasma free fatty acids become elevated

• reduced GLP-1 levels when plasma free fatty acids become elevated

decreased circulating glucagon level ( J:141957 )

• when plasma free fatty acids become elevated

abnormal circulating insulin level ( J:141957 )

• the increase in plasma insulin resulting from elevated plasma free fatty acids is only half the increase seen in controls

abnormal triglyceride level ( J:141957 )

decreased circulating triglyceride level ( J:141957 )

• on a low fat diet

increased liver triglyceride level ( J:141957 )

• in the liver when on a low fat diet

behavior/neurological

increased food intake ( J:141957 )

• higher food intake than controls on a low fat diet

liver/biliary system

increased liver triglyceride level ( J:141957 )

• in the liver when on a low fat diet

Genotype
MGI:4818770

hm3

• Allelic Composition: Ffar1^tm1Dgen/Ffar1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

taste/olfaction

abnormal gustatory system physiology ( J:161517 )

• show a diminished preference for linoleic acid in a 2 bottle preference test

• glossopharyngeal nerve responses to oleic acid, linoleic acid, linolenic acid, or lauric acid are diminished compared to responses in control mice

• however, no differences are detected in the responses of the chorda tympani

abnormal taste sensitivity ( J:161517 )

• indifferent to all concentrations of linoleic acid and oleic acid suggesting a profound defect in the ability to taste these fatty acids

• no differences are detected in taste sensitivity for bitter, sweet, sour, salty or umami

nervous system

abnormal sensory neuron physiology ( J:161517 )

• glossopharyngeal nerve responses to oleic acid, linoleic acid, linolenic acid, or lauric acid are diminished compared to responses in control mice

• however, no differences are detected in the responses of the chorda tympani