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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cela1-cre/ERT)1Dam
transgene insertion 1, Douglas A Melton
MGI:3821749
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Cela1-cre/ERT)1Dam/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4836240
cn2
 		Krastm4Tyj/Krastm4Tyj
Tg(Cela1-cre/ERT)1Dam/0 		involves: 129S4/SvJae MGI:3821750
cn3
 		Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Tg(Cela1-cre/ERT)1Dam/0 		involves: 129S4/SvJae MGI:5510699
cn4
 		Krastm4Tyj/Kras+
Tg(Cela1-cre/ERT)1Dam/0 		involves: 129S4/SvJae MGI:5510700
cn5
 		Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Krastm4Tyj/Krastm4Tyj
Tg(Cela1-cre/ERT)1Dam/0 		involves: 129S4/SvJae * 129S4/SvJaeSor MGI:3821751
cn6
 		Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Tg(Cela1-cre/ERT)1Dam/0 		involves: 129S6/SvEvTac MGI:5510697


Genotype
MGI:4836240
cn1
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Cela1-cre/ERT)1Dam/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:102226 )
N
• 4 weeks after tamoxifen injections to induce Cre expression, pancreata exhibit no ductal metaplasia




Genotype
MGI:3821750
cn2
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Tg(Cela1-cre/ERT)1Dam/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• tamoxifen treated and untreated mice develop pancreatic intraepithelial neoplasia (PanIN) that develops from acinar cells

endocrine/exocrine glands
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• tamoxifen treated and untreated mice develop pancreatic intraepithelial neoplasia (PanIN) that develops from acinar cells




Genotype
MGI:5510699
cn3
Allelic
Composition		 Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Tg(Cela1-cre/ERT)1Dam/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pdpk1tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:197054 )
N
• mice do not develop pancreatic tumors unlike Krastm4Tyj/Kras+ Tg(Ela1-cre/ERT)1Dam mice

respiratory system




Genotype
MGI:5510700
cn4
Allelic
Composition		 Krastm4Tyj/Kras+
Tg(Cela1-cre/ERT)1Dam/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm

respiratory system

endocrine/exocrine glands




Genotype
MGI:3821751
cn5
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Krastm4Tyj/Krastm4Tyj
Tg(Cela1-cre/ERT)1Dam/0
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• tamoxifen treated and untreated mice develop widespread pancreatic intraepithelial neoplasia (PanIN) that develops from acinar cells
• PanINs proceed to more severe stages than in Krastm4Tyj/Krastm4Tyj Tg(Ela1-cre/ESR1)1Dam mice
• acinar-ductal metaplasia precedes PanIN

endocrine/exocrine glands
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• tamoxifen treated and untreated mice develop widespread pancreatic intraepithelial neoplasia (PanIN) that develops from acinar cells
• PanINs proceed to more severe stages than in Krastm4Tyj/Krastm4Tyj Tg(Ela1-cre/ESR1)1Dam mice
• acinar-ductal metaplasia precedes PanIN




Genotype
MGI:5510697
cn6
Allelic
Composition		 Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Tg(Cela1-cre/ERT)1Dam/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Pik3ca*)Dsa mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
pancreatic acinar-to-ductal metaplasia ( J:197054 )
• induction of acinar to ductal metaplasia

neoplasm




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory