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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igf1tm2Arge
targeted mutation 2, Argiris Efstratiadis
MGI:3821754
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igf1tm2Arge/Igf1tm2Arge involves: 129S/SvEv * C57BL/6J MGI:3821760
ht2
 		Igf1tm2Arge/Igf1tm2.1Arge involves: 129S/SvEv * C57BL/6J * CBA MGI:3821764
cn3
 		Igf1tm2Arge/Igf1tm2Arge
Tg(SERPINA1-cre)1Arge/0 		involves: 129S/SvEv * C57BL/6J MGI:3821761
cn4
 		Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0 		involves: 129S/SvEv * C57BL/6J * CBA MGI:3821763


Genotype
MGI:3821760
hm1
Allelic
Composition		 Igf1tm2Arge/Igf1tm2Arge
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2Arge mutation (0 available); any Igf1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:142247 )
• only 11% of neonates survive
neonatal lethality, incomplete penetrance ( J:142247 )
• only 11% of neonates survive

reproductive system

growth/size/body
decreased body weight ( J:142247 )
• mice weigh 34% of wild-type
postnatal growth retardation ( J:142247 )

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at P72, IGF1 serum levels are below detectable levels

skeleton
abnormal long bone epiphyseal plate proliferative zone ( J:142247 )
• the proliferative zone is half the size of the hypertrophic zone unlike in wild-type mice
decreased long bone epiphyseal plate size ( J:142247 )
• the proliferative zone and hypertrophic zone of the tibia growth plates are decreased compared to in wild-type mice




Genotype
MGI:3821764
ht2
Allelic
Composition		 Igf1tm2Arge/Igf1tm2.1Arge
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (29 available)
Igf1tm2Arge mutation (0 available); any Igf1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 54% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 21% of normal
• at P72, IGF1 serum levels are 26% of normal




Genotype
MGI:3821761
cn3
Allelic
Composition		 Igf1tm2Arge/Igf1tm2Arge
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2Arge mutation (0 available); any Igf1 mutation (29 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:142247 )
• only 11% of neonates survive
neonatal lethality, incomplete penetrance ( J:142247 )
• only 11% of neonates survive

reproductive system
reproductive system phenotype ( J:142247 )
N
• unlike Igf1tm2Arge homozygotes, mice are fertile

growth/size/body
decreased body weight ( J:142247 )
• mice weigh 50% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are below detectable levels
• at P72, IGF1 serum levels are 44% of normal




Genotype
MGI:3821763
cn4
Allelic
Composition		 Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (29 available)
Igf1tm2Arge mutation (0 available); any Igf1 mutation (29 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 61% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 24% of normal
• at P72, IGF1 serum levels are 60% of normal




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory