All Phenotypes Tg(SERPINA1-cre)1Arge MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(SERPINA1-cre)1Arge
transgene insertion 1, Argiris Efstratiadis
MGI:3821757

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccar2^tm1Dac/Ccar2^tm1Dac Sirt1^tm1Ygu/Sirt1^tm1Ygu Tg(SERPINA1-cre)1Arge/0	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5804112
cn2	Igf1^tm2Arge/Igf1^tm2Arge Tg(SERPINA1-cre)1Arge/0	involves: 129S/SvEv * C57BL/6J	MGI:3821761
cn3	Igf1^tm2Arge/Igf1^tm2.1Arge Tg(SERPINA1-cre)1Arge/0	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3821763

Allelic Composition	Ccar2^tm1Dac/Ccar2^tm1Dac Sirt1^tm1Ygu/Sirt1^tm1Ygu Tg(SERPINA1-cre)1Arge/0
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccar2^tm1Dac mutation (0 available); any Ccar2 mutation (40 available)
Sirt1^tm1Ygu mutation (2 available); any Sirt1 mutation (81 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:228688 )

N	• normal body weight and fat content

decreased susceptibility to diet-induced obesity ( J:228688 )

• mice fed a high-fat diet gain less weight than controls and show no increase in body fat

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:228688 )

N	• normal glucose tolerance

decreased susceptibility to diet-induced obesity ( J:228688 )

• mice fed a high-fat diet gain less weight than controls and show no increase in body fat

Allelic Composition	Igf1^tm2Arge/Igf1^tm2Arge Tg(SERPINA1-cre)1Arge/0
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm2Arge mutation (0 available); any Igf1 mutation (29 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:142247 )

• only 11% of neonates survive

neonatal lethality, incomplete penetrance ( J:142247 )

• only 11% of neonates survive

reproductive system

reproductive system phenotype ( J:142247 )

N	• unlike Igf1^tm2Arge homozygotes, mice are fertile

growth/size/body

decreased body weight ( J:142247 )

• mice weigh 50% of wild-type

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:142247 )

• at E18.5, IGF1 serum levels are below detectable levels

• at P72, IGF1 serum levels are 44% of normal

Allelic Composition	Igf1^tm2Arge/Igf1^tm2.1Arge Tg(SERPINA1-cre)1Arge/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm2.1Arge mutation (0 available); any Igf1 mutation (29 available)
Igf1^tm2Arge mutation (0 available); any Igf1 mutation (29 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:142247 )

• mice weigh 61% of wild-type

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:142247 )

• at E18.5, IGF1 serum levels are 24% of normal

• at P72, IGF1 serum levels are 60% of normal

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