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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flrt3tm1Kln
targeted mutation 1, Rudiger Klein
MGI:3821876
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flrt3tm1Kln/Flrt3tm1Kln involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3821878
ht2
 		Flrt3tm1Kln/Flrt3tm2Kln involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3821879


Genotype
MGI:3821878
hm1
Allelic
Composition		 Flrt3tm1Kln/Flrt3tm1Kln
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flrt3tm1Kln mutation (0 available); any Flrt3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:142039 )
• by P15 less than 3% of mice are viable




Genotype
MGI:3821879
ht2
Allelic
Composition		 Flrt3tm1Kln/Flrt3tm2Kln
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flrt3tm1Kln mutation (0 available); any Flrt3 mutation (44 available)
Flrt3tm2Kln mutation (0 available); any Flrt3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal anterior visceral endoderm morphology ( J:142039 )
• 19 of 24 mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm

cellular
abnormal basement membrane morphology ( J:142039 )
• 19 of 24 mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory