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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(MYC/ERT2)Gev
targeted mutation 1, Gerard Evan
MGI:3821930
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev involves: C57BL/6 * FVB/N MGI:3821932
cn2
 		Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev
Krastm4Tyj/Krastm4Tyj 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3821936


Genotype
MGI:3821932
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MYC/ERT2)Gev mutation (0 available); any Gt(ROSA)26Sor mutation (1024 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
preneoplasia ( J:142030 )
• after 3 weeks, mice treated with adenovirus cre via intranasal delivery and exposed to tamoxifen develop multiple hyperplastic and dysplastic epithelial foci with pseudotratification and occasional micropapillary tuft formation in the lungs unlike in similarly treated wild-type mice
• after 6 weeks, mice treated with adenovirus cre via intranasal delivery and exposed to tamoxifen exhibit extensive micropapillary and papillary hyperplasia with several bronchioles exhibiting Clara cell hyperplasia and sloughing into the airway lumen unlike similarly treated wild-type mice




Genotype
MGI:3821936
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev
Krastm4Tyj/Krastm4Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MYC/ERT2)Gev mutation (0 available); any Gt(ROSA)26Sor mutation (1024 available)
Krastm4Tyj mutation (12 available); any Kras mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:142030 )
• following intranasal treatment with adenovirus cre only, mice exhibit hyperplastic and dysplastic bronchiolar lesions unlike similarly treated wild-type mice but similar to in cre-activated Krastm4Tyj homozygotes
• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen, mice develop large and numerous papillary adenomas that are poorly differentiated and grow in small tumor clusters with individual cells embedded within desmoplastic stroma
increased lung adenoma incidence ( J:142030 )
• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen

respiratory system
increased lung tumor incidence ( J:142030 )
• following intranasal treatment with adenovirus cre only, mice exhibit hyperplastic and dysplastic bronchiolar lesions unlike similarly treated wild-type mice but similar to in cre-activated Krastm4Tyj homozygotes
• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen, mice develop large and numerous papillary adenomas that are poorly differentiated and grow in small tumor clusters with individual cells embedded within desmoplastic stroma
increased lung adenoma incidence ( J:142030 )
• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory