Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MYC/ERT2)Gev mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(994 available)
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neoplasm
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• after 3 weeks, mice treated with adenovirus cre via intranasal delivery and exposed to tamoxifen develop multiple hyperplastic and dysplastic epithelial foci with pseudotratification and occasional micropapillary tuft formation in the lungs unlike in similarly treated wild-type mice
• after 6 weeks, mice treated with adenovirus cre via intranasal delivery and exposed to tamoxifen exhibit extensive micropapillary and papillary hyperplasia with several bronchioles exhibiting Clara cell hyperplasia and sloughing into the airway lumen unlike similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MYC/ERT2)Gev mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(994 available)
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(84 available)
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neoplasm
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• following intranasal treatment with adenovirus cre only, mice exhibit hyperplastic and dysplastic bronchiolar lesions unlike similarly treated wild-type mice but similar to in cre-activated Krastm4Tyj homozygotes
• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen, mice develop large and numerous papillary adenomas that are poorly differentiated and grow in small tumor clusters with individual cells embedded within desmoplastic stroma
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• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen
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respiratory system
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• following intranasal treatment with adenovirus cre only, mice exhibit hyperplastic and dysplastic bronchiolar lesions unlike similarly treated wild-type mice but similar to in cre-activated Krastm4Tyj homozygotes
• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen, mice develop large and numerous papillary adenomas that are poorly differentiated and grow in small tumor clusters with individual cells embedded within desmoplastic stroma
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• 6 weeks following intranasal exposure to adenovirus cre and treatment with tamoxifen
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Analysis Tools