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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmp2tm1.1Mis
targeted mutation 1.1, Yuji Mishina
MGI:3822027
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Bmp2tm1Brd/Bmp2tm1.1Mis involves: 129S/SvEv * C57BL/6J MGI:3822029
cn2
 		Bmp2tm1Brd/Bmp2tm1.1Mis
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:4430833
cn3
 		Bmp2tm1Brd/Bmp2tm1.1Mis
Gfi1tm1(cre)Gan/Gfi1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:4430834
cn4
 		Bmp2tm1.1Mis/Bmp2tm1.2Mis
Tg(Col1a1-cre)1Bek/0 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CD-1 MGI:5572807


Genotype
MGI:3822029
ht1
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1.1Mis
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:141834 )
N
• the expected proportion of trans-heterozygous pups are detected, unlike for mice trans-heterozygous for Bmp2tm1Brd and Bmp2tm1Mis




Genotype
MGI:4430833
cn2
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1.1Mis
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:156945 )
N
• no obvious abnormalities in cochlea morphology is observed




Genotype
MGI:4430834
cn3
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1.1Mis
Gfi1tm1(cre)Gan/Gfi1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:156945 )
• a 6.5 dB shift in threshold is detected at 16kHz in 3-6 month-old mice compared to controls; at 9-10 months, hearing thresholds are comparable to controls




Genotype
MGI:5572807
cn4
Allelic
Composition		 Bmp2tm1.1Mis/Bmp2tm1.2Mis
Tg(Col1a1-cre)1Bek/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1.2Mis mutation (0 available); any Bmp2 mutation (27 available)
Tg(Col1a1-cre)1Bek mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
short humerus ( J:210409 )
• at 2 weeks but not 2-4 months
abnormal vertebral column morphology ( J:210409 )
• enlarged intervertebral space in the vertebrae
small vertebrae ( J:210409 )
• slight at 2 weeks
• at 4 months
• in the lumbar vertebrae and hip region
vertebral fusion ( J:210409 )
• smaller unfused at 2 weeks
abnormal bone structure ( J:210409 )
• thinner bones at 2 weeks, progressive
impaired osteoblast differentiation ( J:210409 )
• reduced mesenchymal stem cell population and capacity to differentiate to mature osteoblasts
decreased osteoclast cell number ( J:210409 )
• decrease in osteoclasts covering bone surface or number of osteoclasts per unit of bone surface at 2 weeks
decreased bone volume ( J:210409 )
• in the tibia, femur and humerus
• however, cortical thickness is normal
decreased osteoblast cell number ( J:210409 )
• fewer mature cuboidal polarized osteoblasts from 5 days to 6 months
• decrease in the region of mature osteoblasts covering the bone surface and number of mature osteoblasts per bone surface at 8 weeks
abnormal trabecular bone morphology ( J:210409 )
• increase in rod-like quality of trabeculae
decreased bone mineralization ( J:210409 )
• reduced bone mineralizing surface and mineral apposition rate in the bone marrow trabeculae and in the periosteum
decreased bone ossification ( J:210409 )
• decreased bone formation
fragile skeleton ( J:210409 )
• more brittle

cardiovascular system
abnormal vascular development ( J:210409 )
• decreased vascularization in the bone (diaphysis and metaphysis)

limbs/digits/tail
short humerus ( J:210409 )
• at 2 weeks but not 2-4 months

cellular
impaired osteoblast differentiation ( J:210409 )
• reduced mesenchymal stem cell population and capacity to differentiate to mature osteoblasts

immune system
decreased osteoclast cell number ( J:210409 )
• decrease in osteoclasts covering bone surface or number of osteoclasts per unit of bone surface at 2 weeks

hematopoietic system
decreased osteoclast cell number ( J:210409 )
• decrease in osteoclasts covering bone surface or number of osteoclasts per unit of bone surface at 2 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory