Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh7-Ptpn11*Q79R)11Rbns transgene insertion 11, Jeffrey Robbins MGI:3822132 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, heart weight, ventricular compaction, cardiac cell proliferation and heart function are normal
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| N |
• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, lung weight is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, heart weight, ventricular compaction, cardiac cell proliferation and heart function are normal
|
| N |
• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, lung weight is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 39% of mice die by 8 months of age
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• postmortem
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• at E16.5
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• at E16.5, mice exhibit ventricular noncompaction unlike in wild-type mice that persists postnatally without fibrosis
• cells in the noncompacted ventricle exhibit increased proliferation compared to in wild-type mice
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• postmortem
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• cells in the noncompacted ventricle and located at the boundaries of the muscular ventricular septum and atrioventricular cushion tissue exhibit increased proliferation compared to in wild-type mice
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• postmortem, mice display chronic left atria thrombi unlike in wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Noonan syndrome 1 | DOID:0060578 |
OMIM:163950 |
J:123963 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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