Phenotypes associated with this allele

• Allele Symbol: Mir133a-2^tm1.1Eno
• Allele Name: targeted mutation 1.1, Eric N Olson
• Allele ID: MGI:3822158
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3822177
cx2	Mir133a-1^tm1.1Eno/Mir133a-1^tm1.1Eno Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3822175

Genotype
MGI:3822177

hm1

• Allelic Composition: Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:142220 )

• mice are viable

Genotype
MGI:3822175

cx2

• Allelic Composition: Mir133a-1^tm1.1Eno/Mir133a-1^tm1.1Eno; Mir133a-2^tm1.1Eno/Mir133a-2^tm1.1Eno
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

mortality/aging

neonatal lethality, incomplete penetrance ( J:142220 )

• underrepresented at birth, and 50% of the remaining mice die within the first postnatal day

• ~24% of total dKO mice survived to adulthood

prenatal lethality, incomplete penetrance ( J:142220 )

• analysis of offspring from timed matings of heterozygous mutant mice revealed dKO mutant embryos between embryonic day 10.5 (E10.5) and E17.5 at a frequency slightly less than Mendelian with occasional dead dKO embryos

cardiovascular system

abnormal heart morphology ( J:142220 )

abnormal myocardial fiber morphology ( J:142220 )

dilated heart atrium ( J:142220 )

enlarged heart ( J:142220 )

abnormal heart ventricle morphology ( J:142220 )

abnormal interventricular septum morphology ( J:142220 )

abnormal heart right ventricle morphology ( J:142220 )

thin ventricular wall ( J:142220 )

cardiac fibrosis ( J:142220 )

abnormal cardiovascular system physiology ( J:142220 )

dilated cardiomyopathy ( J:142220 )

decreased cardiac muscle contractility ( J:142220 )

decreased heart ventricle muscle contractility ( J:142220 )

muscle

abnormal myocardial fiber morphology ( J:142220 )

dilated cardiomyopathy ( J:142220 )

decreased cardiac muscle contractility ( J:142220 )

decreased heart ventricle muscle contractility ( J:142220 )

increased cardiomyocyte apoptosis ( J:142220 )

cellular

increased cardiomyocyte apoptosis ( J:142220 )

growth/size/body

enlarged heart ( J:142220 )