Phenotypes associated with this allele

• Allele Symbol: Ifnar1^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3822164
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1^m1Btlr	MGI:3822165

Genotype
MGI:3822165

hm1

• Allelic Composition: Ifnar1^m1Btlr/Ifnar1^m1Btlr
• Genetic Background: C57BL/6J-Ifnar1^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:142790 )

N • signaling via the Toll-like receptors (TLRs) induces production of normal levels of tumor necrosis factor alpha (TNFalpha) by mutant macrophages

abnormal macrophage physiology ( J:142790 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by mouse cytomegalovirus (MCMV), influenza virus, Rift Valley fever virus (RVFV) or an adenovirus vector

decreased interferon-alpha secretion ( J:142790 )

• preliminary evidence suggests these macrophages produce lower levels of type 1 interferons (IFNs) than do wild type macrophages in response to adenovirus infection

decreased interferon-beta secretion ( J:142790 )

• preliminary evidence suggests these macrophages produce lower levels of type 1 interferons (IFNs) than do wild type macrophages in response to adenovirus infection

increased susceptibility to Adenoviridae infection ( J:142790 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by an adenovirus vector

increased susceptibility to Herpesvirales infection ( J:142790 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by mouse cytomegalovirus (MCMV)

increased susceptibility to Riboviria infection ( J:142790 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by Rift Valley fever virus (RVFV)

increased susceptibility to Orthomyxoviridae infection ( J:142790 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by influenza virus

hematopoietic system

abnormal macrophage physiology ( J:142790 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by mouse cytomegalovirus (MCMV), influenza virus, Rift Valley fever virus (RVFV) or an adenovirus vector