Analysis Tools|
Allele Symbol Allele Name Allele ID |
Spint1tm1Bug targeted mutation 1, Thomas H Bugge MGI:3822295 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• normal development until E9.5 followed by severe growth retardation
• homozygous embryos all resorbed by E12.5
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• after E9.5
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• chorionic trophoblast fails to grow in toward the spongial layer at E9.5
• chorionic trophoblast layer fails to continue normal differentiation after E9.0
• disorganized laminin deposition seen at E9.0
• chorionic trophoblasts present only as scattered clusters of cells at E9.5
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• after E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• survive past E10.5, unlike mice homozygous for Spint1tm1Bug alone
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| N |
• rescue of placental defects seen in mice homozygous for Spint1tm1Bug alone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double homozygotes born at near normal numbers
• die within the first day after birth
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| N |
• placentas normal, including labyrinth layer
• no growth retardation
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• 75% of double homozygous mutant pups lack milk spots in the stomach
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• absence of erupted whiskers
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• reddish, wrinkled, dry
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• tightly packed immature corneocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• double homozygotes born at near normal numbers
• die within the first day after birth
|
| N |
• placentas normal, including labyrinth layer
• no growth retardation
|
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• 75% of double homozygous mutant pups lack milk spots in the stomach
|
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• absence of erupted whiskers
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• reddish, wrinkled, dry
|
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• tightly packed immature corneocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• many mice survive to term unlike mutant mice carrying at least 1 wild-type allele of Prss8
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| N |
• no obvious developmental abnormalities are detected between E11.5 and E13.5
• complete rescue of placental labyrinth defects seen in mice homozygous for Spint1tm1Bug alone
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• outwardly indistinguishable from littermates homozygous for Prss8fr alone at up to 1 year of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• placental differentiation defects
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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