Phenotypes associated with this allele

• Allele Symbol: Tg(Cyp21a1-Apoe)619Fet
• Allele Name: transgene insertion 619, Fayanne Thorngate
• Allele ID: MGI:3822316
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(Cyp21a1-Apoe)619Fet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3822449
tg2	Tg(Cyp21a1-Apoe)619Fet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3822448

Genotype
MGI:3822449

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(Cyp21a1-Apoe)619Fet/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating apolipoprotein E level ( J:130658 )

• mice have very reduced levels of Apoe (0-2 ug/ml) compared to wild-type plasma Apoe levels

abnormal lipid level ( J:130658 )

• plasma lipoprotein profiles are indistinguishable from Apoe-null nontransgenic littermates; LDL and VLDL distributions are similar to Apoe-deficient mice

increased circulating cholesterol level ( J:130658 )

• total plasma cholesterol levels (TPC) are about 580 mg/dl (mean TPC approx 302 mg/dl) compared to control mice (70-100 mg/dl); mice are hypercholesterolemic, similar to non-transgenic Apoe-deficient mice

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130658 )

• almost no lesion staining is observed in mice between 7.5 months to >2.5 years of age, despite persistent hypercholesterolemia, but lesions are observed throughout aortas of nontransgenic Apoe-null littermates

• aorta cholesteryl ester (CE) depositions are reduced by 86% compared to nontransgenic Apoe-null littermates

Genotype
MGI:3822448

tg2

• Allelic Composition: Tg(Cyp21a1-Apoe)619Fet/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

homeostasis/metabolism

increased circulating cholesterol level ( J:130658 )

• total plasma cholesterol levels (TPC) are about 646 mg/dl (mean TPC approx 662 mg/dl)