nervous system
N |
• no paroxysmal EEG activity
• no epileptic seizures
|
• absolute EEG power densities show a slight but significant elevation
|
• significant reduction in inhibition by a low intensity prepulse
• inhibition due to a high intensity prepulse is normal
|
behavior/neurological
N |
• performance normal in rotarod, open field, and shuttle box tests
• normal performance in a Morris water maze
• generally normal responses in anxiety related tests although some trends are noted
|
• preference for closed compartment in elevated maze
• increased tendency to stay in illuminated areas in light/dark avoidance tests
|
• increased startle response
|
homeostasis/metabolism
N |
• plasma glucose and insulin normal
• triglyceride, free fatty acids, and cholesterol all normal
|
growth/size/body
N |
• normal
|