Analysis Tools
homeostasis/metabolism
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• at 14 to 16 weeks of age, mice exhibit 28% lower plasma magnesium levels than in wild-type mice
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hypokalemia
(
J:122766
)
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• plasma potassium levels are 17% lower than in wild-type mice
|
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• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice
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• fractional excretion of potassium is 2-fold more than in wild-type mice
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• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice
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renal/urinary system
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• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice
|
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• fractional excretion of potassium is 2-fold more than in wild-type mice
|
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• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice
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• at 6 months, mice exhibit calcium deposits in the basement membrane of the medullary tubules and the surrounding interstitium unlike in wild-type mice
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cardiovascular system
hypotension
(
J:122766
)
skeleton
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• when fed a calcium poor diet, mice exhibit a decrease in bone mineral content compared to similarly treated wild-type mice
• however, mice exhibit normal bone mineral content on a standard diet
|
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• when fed a calcium poor diet, mice exhibit a decrease in bone mineral density compared to similarly treated wild-type mice
• however, mice exhibit normal bone mineral density on a standard diet
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| renal hypomagnesemia 3 | DOID:0060880 |
OMIM:248250 |
J:122766 | |
