Phenotypes associated with this allele

• Allele Symbol: Epb41l5^tm1Sia
• Allele Name: targeted mutation 1, Shinichi Aizawa
• Allele ID: MGI:3822451
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epb41l5^tm1Sia/Epb41l5^tm1Sia	Not Specified	MGI:3822464

Genotype
MGI:3822464

hm1

• Allelic Composition: Epb41l5^tm1Sia/Epb41l5^tm1Sia
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Epb41l5^tm1Sia/Epb41l5^tm1Sia mice display mesodermal and epithelial-mesenchymal transition defects

embryo

abnormal developmental patterning ( J:142596 )

abnormal germ layer development ( J:142596 )

abnormal ectoderm development ( J:142596 )

• loss of columnar epithelial shape

• multiple layers

• minimal intercellular spaces

• normal tight junctions, adherens junctions, and desmosomes apically but not elsewhere

• basement membrane barely detectable

abnormal endoderm development ( J:142596 )

• tight intercellular contacts between endoderm cells

• no basement membrane

abnormal mesoderm development ( J:142596 )

• differentiating at E7.5 but migrating poorly

• few intercellular spaces among invaginating mesoderm cells

abnormal rostral-caudal axis patterning ( J:142596 )

• head fold development at E8.5 is poor with a minimum of mesoderm

decreased embryo size ( J:142596 )

• reduced in size at E6.5

• E6.5 embryos histologically normal despite size

abnormal neural plate morphology ( J:142596 )

• multiple cell layers at E8.5

abnormal embryonic neuroepithelium morphology ( J:142596 )

• neuroectoderm is hypertrophic at E8.5

absent somites ( J:142596 )

• pre-somitic mesoderm is generated but segmented somites never form

nervous system

abnormal neural plate morphology ( J:142596 )

• multiple cell layers at E8.5

abnormal embryonic neuroepithelium morphology ( J:142596 )

• neuroectoderm is hypertrophic at E8.5

growth/size/body

decreased embryo size ( J:142596 )

• reduced in size at E6.5

• E6.5 embryos histologically normal despite size

digestive/alimentary system

abnormal foregut morphology ( J:142596 )

• foregut fails to close