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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lhb-cre)1Sac
transgene insertion 1, Sally A Camper
MGI:3822455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pitx2tm1Sac/Pitx2tm2Sac
Tg(Lhb-cre)1Sac/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL MGI:3822456
cn2
 		Ppargtm2Rev/Ppargtm2Rev
Tg(Lhb-cre)1Sac/? 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:5444194


Genotype
MGI:3822456
cn1
Allelic
Composition		 Pitx2tm1Sac/Pitx2tm2Sac
Tg(Lhb-cre)1Sac/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pitx2tm1Sac mutation (0 available); any Pitx2 mutation (39 available)
Pitx2tm2Sac mutation (0 available); any Pitx2 mutation (39 available)
Tg(Lhb-cre)1Sac mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:142726 )
N
• unlike Pitx2 null mice, mice exhibit normal gonadal development, puberty and fertility

growth/size/body
growth/size/body region phenotype ( J:142726 )
N
• unlike Pitx2 null mice, growth rates and weights are normal




Genotype
MGI:5444194
cn2
Allelic
Composition		 Ppargtm2Rev/Ppargtm2Rev
Tg(Lhb-cre)1Sac/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (41 available)
Tg(Lhb-cre)1Sac mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:170272 )
N
• both males and females are fertile and produce litters at a normal rate
• estrus patterns are normal
abnormal diestrus ( J:170272 )
• diestrus levels of LH are elevated 3-fold

homeostasis/metabolism
decreased circulating follicle stimulating hormone level ( J:170272 )
• plasma levels are slightly but significantly reduced in males whereas levels are normal in females
increased luteinizing hormone level ( J:170272 )
• diestrus levels are elevated 3-fold in females whereas male levels are normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory