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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad3tm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:3822465
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Amhr2tm3(cre)Bhr/Amhr2+
Smad3tm1Par/Smad3tm1Zuk 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3822484
cn2
 		Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
Smad3tm1Par/Smad3tm1Zuk 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3822485


Genotype
MGI:3822484
cn1
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Smad3tm1Par/Smad3tm1Zuk
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Smad3tm1Par mutation (2 available); any Smad3 mutation (22 available)
Smad3tm1Zuk mutation (0 available); any Smad3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:142827 )
N
• mice exhibit normal reproductive morphology and physiology




Genotype
MGI:3822485
cn2
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
Smad3tm1Par/Smad3tm1Zuk
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Smad2tm1.1Mwst mutation (0 available); any Smad2 mutation (52 available)
Smad2tm1Cxd mutation (0 available); any Smad2 mutation (52 available)
Smad3tm1Par mutation (2 available); any Smad3 mutation (22 available)
Smad3tm1Zuk mutation (0 available); any Smad3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased oocyte number ( J:142827 )
• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice

reproductive system
decreased oocyte number ( J:142827 )
• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice
abnormal ovarian follicle morphology ( J:142827 )
• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
decreased tertiary ovarian follicle number ( J:142827 )
• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
increased atretic ovarian follicle number ( J:142827 )
• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
abnormal cumulus expansion ( J:142827 )
• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
premature ovarian failure ( J:142827 )
• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice

homeostasis/metabolism

mortality/aging
premature ovarian failure ( J:142827 )
• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:142827 )
• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
decreased tertiary ovarian follicle number ( J:142827 )
• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
increased atretic ovarian follicle number ( J:142827 )
• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
abnormal cumulus expansion ( J:142827 )
• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
premature ovarian failure ( J:142827 )
• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory