All Phenotypes Hesx1<tm1(cre)Jpmb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hesx1^tm1(cre)Jpmb
targeted mutation 1, Juan Pedro Martinez Barbera
MGI:3822473

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb	B6.129S-Hesx1^tm1(cre)Jpmb	MGI:3822764
hm2	Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb	involves: 129S/SvEv	MGI:5314530
ht3	Hesx1^tm1(cre)Jpmb/Hesx1⁺	involves: 129S/SvEv	MGI:5314529
ht4	Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar	involves: 129P2/OlaHsd * 129S/SvEv	MGI:5314531
cn5	Ctnnb1^tm1Max/Ctnnb1^tm2Kem Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5314536
cn6	Ctnnb1^tm2Kem/Ctnnb1⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar	involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:5314537
cn7	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:3822771
cn8	Hesx1^tm1(cre)Jpmb/Hesx1⁺ Tcf7l1^tm1Efu/Tcf7l1^tm2Efu	involves: 129S/SvEv	MGI:5314534
cn9	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm2Jpmb	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:3822877
cn10	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm3Jpmb	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:3822876
cn11	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1⁺	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:3822878
cn12	Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb} Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3822770
cn13	Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3822769
cx14	Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar Tcf7l1^tm2Efu/Tcf7l1⁺	involves: 129P2/OlaHsd * 129S/SvEv	MGI:5314533
cx15	Ctnnb1^tm1Max/Ctnnb1⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar	involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:5314535

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb
Genetic Background	B6.129S-Hesx1^tm1(cre)Jpmb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:135132 )

• no homozygous offspring are identified

nervous system

abnormal telencephalon development ( J:135132 )

• mice show reduced or absent telencephalon at 12.5 dpc (days post coitum)

vision/eye

abnormal eye development ( J:135132 )

• eye defects are fully penetrant with variable expressivity

microphthalmia ( J:135132 )

• some embryos display unilateral microphthalmia

anophthalmia ( J:135132 )

• some embryos display bilateral anophthalmia

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal anterior eye segment morphology ( J:181005 )

• partial penetrance and displayed a variable range of anterior defects

microphthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

nervous system

small embryonic telencephalon ( J:181005 )

• in some mice

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:181005 )

• low incidence of unilateral microphthalmia

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1^tm1Icar mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal anterior eye segment morphology ( J:181005 )

• partial penetrance and displayed a variable range of anterior defects

microphthalmia ( J:181005 )

• bilateral in some mice

• unilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

nervous system

small embryonic telencephalon ( J:181005 )

• in some mice

Allelic Composition	Ctnnb1^tm1Max/Ctnnb1^tm2Kem Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Max mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1^tm1Icar mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

nervous system

small embryonic telencephalon ( J:181005 )

• in some mice

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1^tm1Icar mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:181005 )

small embryonic telencephalon ( J:181005 )

• in some mice

vision/eye

microphthalmia ( J:181005 )

• bilateral in some mice

• unilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1^tm1Icar mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:135132 )

• telencepepahlic vesicle development is often asymmetric in embryos, with the right side being more severely affected

• very small telencephalic vesicle is sometimes observed at the 8-10 somite stage

vision/eye

abnormal optic vesicle formation ( J:135132 )

• development of optic vesicles is often asymmetric with right side more severely affected

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1⁺ Tcf7l1^tm1Efu/Tcf7l1^tm2Efu
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Tcf7l1^tm1Efu mutation (0 available); any Tcf7l1 mutation (84 available)
Tcf7l1^tm2Efu mutation (0 available); any Tcf7l1 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

nervous system

small embryonic telencephalon ( J:181005 )

• in some mice

decreased forebrain size ( J:181005 )

• severe truncation in some mice

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm2Jpmb
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1^tm2Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased forebrain size ( J:142649 )

• anterior to posterior cell fate transformation is detected at 10 days post coitum, resulting in anterior forebrain reduction

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm3Jpmb
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1^tm3Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased forebrain size ( J:142649 )

• anterior to posterior cell fate transformation is detected at 10 days post coitum, resulting in anterior forebrain reduction

• alterations are more severe than observed in corresponding Hesx1^tm2Jpmb compound mutants

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:142649 )

Allelic Composition	Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb} Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:135132 )

N	• number of mice identified at weaning is similar to the expected numbers

vision/eye

abnormal eye morphology ( J:135132 )

• all mutants surviving to weaninig age display eye defects

microphthalmia ( J:135132 )

• bilateral microphthalmia was seen in some embryos

anophthalmia ( J:135132 )

• some embryos show bilateral anophthalmia, whereas others have unilateral anophthalmia

Allelic Composition	Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:135132 )

• mice surviving to weaning age are reduced in number when compared to expected numbers

vision/eye

abnormal eye morphology ( J:135132 )

• all mutants surviving to weaninig age display eye defects

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar Tcf7l1^tm2Efu/Tcf7l1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased forebrain size ( J:181005 )

• almost complete loss of most of the anterior forebrain

Allelic Composition	Ctnnb1^tm1Max/Ctnnb1⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Max mutation (0 available); any Ctnnb1 mutation (49 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Hesx1^tm1Icar mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:181005 )

small embryonic telencephalon ( J:181005 )

• in some mice

vision/eye

microphthalmia ( J:181005 )

• bilateral in some mice

• unilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

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