immune system
• mice exhibit a reduction in splenic NK cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
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• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
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• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
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• mice exhibit a reduction in CD44highIL23beta+CD8+ memory T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
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• one month following infection with modified vaccinia Ankara virus, the number of IFN-gamma producing T cells is decreased compared to in similarly treated wild-type mice
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• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells
• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells
• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation
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hematopoietic system
• mice exhibit a reduction in splenic NK cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
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• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
|
• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
|
• mice exhibit a reduction in CD44highIL23beta+CD8+ memory T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
|
• one month following infection with modified vaccinia Ankara virus, the number of IFN-gamma producing T cells is decreased compared to in similarly treated wild-type mice
|
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells
• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells
• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation
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cellular
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells
• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells
• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation
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