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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il15ratm1Wjl
targeted mutation 1, Warren J Leonard
MGI:3822486
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il15ratm1Wjl/Il15ratm1Wjl involves: 129 * C57BL/6 MGI:3822490


Genotype
MGI:3822490
hm1
Allelic
Composition
Il15ratm1Wjl/Il15ratm1Wjl
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Wjl mutation (1 available); any Il15ra mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit a reduction in splenic NK cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• mice exhibit a reduction in CD44highIL23beta+CD8+ memory T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• one month following infection with modified vaccinia Ankara virus, the number of IFN-gamma producing T cells is decreased compared to in similarly treated wild-type mice
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells
• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells
• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation

hematopoietic system
• mice exhibit a reduction in splenic NK cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• mice exhibit a reduction in CD44highIL23beta+CD8+ memory T cells compared to in wild-type mice that is not as severe as in Il15ratm1Ama homozygotes
• one month following infection with modified vaccinia Ankara virus, the number of IFN-gamma producing T cells is decreased compared to in similarly treated wild-type mice
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells
• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells
• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation

cellular
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit decreased proliferation compared to similarly treated wild-type cells
• memory and naive CD8+ T cells cultured with Il-21 plus IL15 (at either 50 ng/mL or 5 ng/mL) exhibit reduced proliferation compared to similarly treated wild-type cells
• however, treatment of TCR-activated CD8+ T cells with 50 ng/mL of IL15 induces normal T cell proliferation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory