Phenotypes associated with this allele

• Allele Symbol: Plk1^{Gt(RRR358)Byg}
• Allele Name: gene trap RRR358, BayGenomics
• Allele ID: MGI:3822515
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plk1^Gt(RRR358)Byg/Plk1^Gt(RRR358)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3822516
ht2	Plk1^Gt(RRR358)Byg/Plk1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3822517

Genotype
MGI:3822516

hm1

• Allelic Composition: Plk1^{Gt(RRR358)Byg}/Plk1^{Gt(RRR358)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:142593 )

embryo

embryonic growth arrest ( J:142593 )

• arrest at the 4 to 8 cell stage

cellular

abnormal cell cycle ( J:142593 )

• at E3.5, embryos lack staining for markers of mitosis

• however, BrdU incorporation suggests initiation of DNA replication does occur

abnormal mitotic spindle morphology ( J:142593 )

• at E3.5, embryos do not contain assembled spindles

Genotype
MGI:3822517

ht2

• Allelic Composition: Plk1^{Gt(RRR358)Byg}/Plk1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased tumor incidence ( J:142593 )

• at 50 - 70 weeks of age, tumor frequency is 27.5% compared to 9% in wild type controls

increased lymphoma incidence ( J:142593 )

• a significant proportion of the tumors are lymphomas that invade the lung and liver

increased lung carcinoma incidence ( J:142593 )

• most of the rest of the tumors are lung carcinomas

increased squamous cell carcinoma incidence ( J:142593 )

• seen in one case

increased sarcoma incidence ( J:142593 )

• one case of ovarian sarcoma was seen

cellular

aneuploidy ( J:142593 )

• splenocytes contain a higher percentage of aneuploidies

respiratory system

increased lung carcinoma incidence ( J:142593 )

• most of the rest of the tumors are lung carcinomas