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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp73tm1Mak
targeted mutation 1, Tak Mak
MGI:3822523
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp73tm1Mak/Trp73tm1Mak involves: 129P2/OlaHsd MGI:5305968
hm2
 		Trp73tm1Mak/Trp73tm1Mak involves: 129P2/OlaHsd * C57BL/6J MGI:3822533
ht3
 		Trp73tm1Mak/Trp73+ involves: 129P2/OlaHsd * C57BL/6J MGI:3822534


Genotype
MGI:5305968
hm1
Allelic
Composition		 Trp73tm1Mak/Trp73tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73tm1Mak mutation (3 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:180144 )
• cultured DIV 5 cortical neurons show a significant reduction in the number of branches resulting in a decrease in dendritic tree complexity




Genotype
MGI:3822533
hm2
Allelic
Composition		 Trp73tm1Mak/Trp73tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73tm1Mak mutation (3 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:142848 )
• all mice die by 25 months
prenatal lethality, incomplete penetrance ( J:142848 )
• fewer than expected mice are born

respiratory system
increased lung adenocarcinoma incidence ( J:142848 )
• 32% of mice develop lung adenocarcinoma

reproductive system
decreased oocyte number ( J:142848 )
• female mice have fewer gametes than wild-type mice
abnormal spindle assembly in female meiosis ( J:142848 )
• spindle abnormalities develop during meiosis
• however, oocytes progress through meiosis and arrest in metaphase II
abnormal meiotic spindle morphology ( J:142848 )
• spindle abnormalities develop during meiosis
abnormal ovarian follicle number ( J:142848 )
• mice possess fewer primordial or early growing follicles compared to in wild-type mice
• however, the number of secondary follicles is normal
abnormal ovulation ( J:142848 )
• during ovulation oocytes remain trapped in the luteinizing granulose cells unlike in wild-type mice
abnormal superovulation ( J:142848 )
• oocytes of mice induced to superovulate are trapped under bursa and do not progress towards the fallopian tubes
failure of superovulation ( J:142848 )
• superovulated females release no oocytes unlike similarly treated wild-type mice
female infertility ( J:142848 )
• despite normal cyclicity and mating behavior, mice are infertile
male infertility ( J:142848 )
• despite mating behavior, mice are infertile

embryo
abnormal embryo development ( J:142848 )
• only 28% of in vitro fertilized oocytes from Trp73tm1Mak homozygous females form blastocysts compared to 75% of wild-type zygotes, and blastocysts that do form arrest in early cleavage

neoplasm
increased incidence of tumors by chemical induction ( J:142848 )
• following treatment with DMBA mice develop tumors following a shorter latency than similarly treated wild-type mice
• however, sites of tumorigenesis following treatment with DMBA are the same as in similarly treated wild-type mice
increased lymphoma incidence ( J:142848 )
• 18% of mice develop lymphoma that infiltrate more than one organ compared to 6% of wild-type mice that develop non-infiltrating lymphoma
increased T cell derived lymphoma incidence ( J:142848 )
• 14% of mice develop thymic lymphoma
increased carcinoma incidence ( J:142848 )
• 9% of mice develop colon carcinoma in situ
increased lung adenocarcinoma incidence ( J:142848 )
• 32% of mice develop lung adenocarcinoma

cellular
decreased oocyte number ( J:142848 )
• female mice have fewer gametes than wild-type mice
abnormal chromosome number ( J:142848 )
• nocodozole treated lung fibroblasts exhibit increased loss of euploidy compared to similarly treated wild-type cells
• however, nocodozole treated thymic cells are euploid
polyploidy ( J:142848 )
• nocodozole treated mouse embryonic fibroblasts exhibit an increase in 8N cells compared to similarly treated wild-type cells
abnormal cell cycle ( J:142848 )
• nocodozole treated mouse embryonic fibroblasts exhibit decreased mitotic arrest compared to similarly treated wild-type cells
abnormal spindle assembly in female meiosis ( J:142848 )
• spindle abnormalities develop during meiosis
• however, oocytes progress through meiosis and arrest in metaphase II
abnormal meiotic spindle morphology ( J:142848 )
• spindle abnormalities develop during meiosis
maternal effect ( J:142848 )
• only 28% of in vitro fertilized oocytes from Trp73tm1Mak homozygous females form blastocysts compared to 75% of wild-type zygotes, and blastocysts that do form arrest in early cleavage

nervous system
abnormal dentate gyrus morphology ( J:142848 )
• at 10 weeks, the dentate gyrus is either completely missing or greatly reduced compared to in wild-type mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:142848 )
• following treatment with DMBA mice develop tumors following a shorter latency than similarly treated wild-type mice
• however, sites of tumorigenesis following treatment with DMBA are the same as in similarly treated wild-type mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:142848 )
• 14% of mice develop thymic lymphoma
abnormal ovarian follicle number ( J:142848 )
• mice possess fewer primordial or early growing follicles compared to in wild-type mice
• however, the number of secondary follicles is normal

immune system
increased T cell derived lymphoma incidence ( J:142848 )
• 14% of mice develop thymic lymphoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:142848 )
• 14% of mice develop thymic lymphoma




Genotype
MGI:3822534
ht3
Allelic
Composition		 Trp73tm1Mak/Trp73+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73tm1Mak mutation (3 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:142848 )
• 10% of mice develop lymphoma that infiltrate more than one organ compared to 6% of wild-type mice that develop non-infiltrating lymphoma
increased T cell derived lymphoma incidence ( J:142848 )
• 5% of mice develop thymic lymphoma
increased carcinoma incidence ( J:142848 )
• 5% of mice develop colon carcinoma in situ
increased lung adenocarcinoma incidence ( J:142848 )
• 5% of mice develop lung adenocarcinoma

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:142848 )
• 5% of mice develop thymic lymphoma

respiratory system
increased lung adenocarcinoma incidence ( J:142848 )
• 5% of mice develop lung adenocarcinoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:142848 )
• 5% of mice develop thymic lymphoma

immune system
increased T cell derived lymphoma incidence ( J:142848 )
• 5% of mice develop thymic lymphoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory