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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rims1tm3Sud
targeted mutation 3, Thomas C Sudhof
MGI:3822548
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rims1tm3Sud/Rims1tm3Sud involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3830687
cn2
 		Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4939900
cx3
 		Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4939901


Genotype
MGI:3830687
cn1
Allelic
Composition		 Rims1tm3Sud/Rims1tm3Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rims1tm3Sud mutation (1 available); any Rims1 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inhibitory postsynaptic currents ( J:143053 )
• hippocampal neurons treated actually or chronically with a cre-expressing lentivirus exhibit a reduced single evoked inhibitory post-synaptic current compared to in wild-type mice




Genotype
MGI:4939900
cn2
Allelic
Composition		 Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rims1tm3Sud mutation (1 available); any Rims1 mutation (88 available)
Rims2tm1.1Sud mutation (1 available); any Rims2 mutation (250 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:168840 )
N
• neurons transfected with a cre-expressing lentivirus exhibit normal morphology with normal synapse size and density
abnormal synaptic vesicle number ( J:168840 )
• neurons transfected with a cre-expressing lentivirus exhibit a 2-fold decrease in the number of docked synaptic vesicles per active zone compared with untransfected cells
abnormal neuron physiology ( J:168840 )
• neurons transfected with a cre-expressing lentivirus exhibit decreased, decelerated, and desynchronized neurotransmitter release; altered calcium dependent release; and impaired presynaptic calcium influx compared with untransfected cells




Genotype
MGI:4939901
cx3
Allelic
Composition		 Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rims1tm3Sud mutation (1 available); any Rims1 mutation (88 available)
Rims2tm1.1Sud mutation (1 available); any Rims2 mutation (250 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:168840 )
• mice are viable and fertile and exhibit no obvious phenotype




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory