Phenotypes associated with this allele

• Allele Symbol: Cdh1^tm1Mlec
• Allele Name: targeted mutation 1, Marc Lecuit
• Allele ID: MGI:3822550
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh1^tm1Mlec/Cdh1^tm1Mlec	involves: 129S2/SvPas	MGI:3822552

Genotype
MGI:3822552

hm1

• Allelic Composition: Cdh1^tm1Mlec/Cdh1^tm1Mlec
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:142843 )

• mice are highly susceptible to Listeria monocytogenes infection

• 48 hours after oral inoculation, 10⁴ or higher CFUs of L. monocytogenes can be recovered from the small intestine, the colon, the cecum and the mesenteric lymph nodes

• intravenous inoculation of pregnant females leads to more fetoplacental invasion by the bacteria than occurs in wild-type mice

• the ratio of bacterial counts between placentas and fetuses 72 hours after inoculation is a difference of more than one order of magnitude than in controls

digestive/alimentary system

abnormal enterocyte physiology ( J:142843 )

• Listeria monocytogenes bacteria bind to and enter enterocytes in vitro in contrast to wild-type controls where bacteria fail to cross the cellular membrane