All Phenotypes Tg(B4galt1-Aurkb*K111R*L323I)1Saco MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(B4galt1-Aurkb*K111R*L323I)1Saco
transgene insertion 1, Paolo Sassone-Corsi
MGI:3822833

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(B4galt1-AurkbK111RL323I)1Saco/0	involves: 129/Sv * C57BL/6J * SJL	MGI:3822906

Allelic Composition	Tg(B4galt1-AurkbK111RL323I)1Saco/0
Genetic Background	involves: 129/Sv * C57BL/6J * SJL

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Using the International Mouse Strain Resource (IMSR)
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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogenesis ( J:142947 )

• binucleate cells form

oligozoospermia ( J:142947 )

• reduced sperm counts

abnormal spermatid morphology ( J:142947 )

• reduced numbers of round and elongated spermatids

abnormal male meiosis ( J:142947 )

• disorganization of spermatogenic stages

• degenerating metaphase I and metaphase II cells

• increased levels of apoptosis

reduced male fertility ( J:142947 )

• male mice are sub fertile

• 48% of males fail to produce litters

cellular