Phenotypes associated with this allele

• Allele Symbol: Slc26a9^tm1Sole
• Allele Name: targeted mutation 1, Manoocher Soleimani
• Allele ID: MGI:3822918
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc26a9^tm1Sole/Slc26a9^tm1Sole	involves: 129S/SvEv	MGI:3823021
ht2	Slc26a9^tm1Sole/Slc26a9^+	involves: 129S/SvEv	MGI:3823025

Genotype
MGI:3823021

hm1

• Allelic Composition: Slc26a9^tm1Sole/Slc26a9^tm1Sole
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gastric mucosa abnormalities in Slc26a9^tm1Sole/Slc26a9^tm1Sole mice

digestive/alimentary system

abnormal gastric chief cell morphology ( J:142516 )

• the number of zymogen cells in the stomach is reduced compared to in wild-type mice

abnormal gastric parietal cell morphology ( J:142516 )

• some parietal cells appear flattened and their numbers are 40% of wild-type

• parietal cells lack tubulovesicles found in wild-type cells

dilated gastric gland ( J:142516 )

• at 5 to 6 weeks of age, mice exhibit dilated gastric glands compared to in wild-type mice

abnormal gastric surface mucous cell morphology ( J:142516 )

• mucus cells contain numerous hyaline granules unlike in wild-type mice

abnormal stomach epithelium morphology ( J:142516 )

• the stomach epithelium is thicker than in wild-type mice

abnormal stomach glandular epithelium morphology ( J:142516 )

• total secretory membranes (apical microvilli, canaicular microvillia and tubulovesicles) are decreased compared to in wild-type stomachs

absent digestive secretion ( J:142516 )

• at 5 to 6 weeks of age, no gastric acid is secreted even when mice are stimulated with forskolin and KCl

decreased digestive secretion ( J:142516 )

• 17 to 19 days, gastric acid secretion is reduced 49% compared to in wild-type mice

• however, mice 7 to 9 days old exhibit normal basal and forskolin-stimulated gastric acid secretion

increased stomach pH ( J:142516 )

• stomach pH is more alkaline than in wild-type mice

endocrine/exocrine glands

abnormal gastric chief cell morphology ( J:142516 )

• the number of zymogen cells in the stomach is reduced compared to in wild-type mice

abnormal gastric parietal cell morphology ( J:142516 )

• some parietal cells appear flattened and their numbers are 40% of wild-type

• parietal cells lack tubulovesicles found in wild-type cells

dilated gastric gland ( J:142516 )

• at 5 to 6 weeks of age, mice exhibit dilated gastric glands compared to in wild-type mice

Genotype
MGI:3823025

ht2

• Allelic Composition: Slc26a9^tm1Sole/Slc26a9⁺
• Genetic Background: involves: 129S/SvEv

digestive/alimentary system

decreased digestive secretion ( J:142516 )

• mice exhibit lower acid secretory peak rates compared to wild-type mice