Phenotypes associated with this allele

• Allele Symbol: Fgfr3^tm2Schl
• Allele Name: targeted mutation 2, Joseph Schlessinger
• Allele ID: MGI:3823026
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr3^tm2Schl/Fgfr3^tm2Schl	involves: 129S1/Sv * CD-1 * FVB/N	MGI:3823047

Genotype
MGI:3823047

hm1

• Allelic Composition: Fgfr3^tm2Schl/Fgfr3^tm2Schl
• Genetic Background: involves: 129S1/Sv * CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone morphology ( J:142946 )

long humerus ( J:142946 )

• 24% longer than controls

long ulna ( J:142946 )

• 9% longer than controls

long femur ( J:142946 )

• 21% longer than controls

long tibia ( J:142946 )

• 14% longer than controls

abnormal long bone epiphyseal plate morphology ( J:142946 )

• height of the growth plate as a whole is increased 38-64% compared to controls

abnormal long bone epiphyseal plate proliferative zone ( J:142946 )

• greatly enlarged in femora and tibia as compared to controls

increased width of hypertrophic chondrocyte zone ( J:142946 )

• in three week old mice

abnormal axial skeleton morphology ( J:142946 )

• longer than controls

kyphosis ( J:142946 )

• mild

abnormal bone structure ( J:142946 )

decreased bone mineral density ( J:142946 )

• bone mineral density is reduced at 6 weeks and at 8 months of age

decreased compact bone thickness ( J:142946 )

• thinner in the femora than in controls

• from 3 weeks old and later

abnormal trabecular bone morphology ( J:142946 )

• trabecular bone of the femora is thinner than controls

• increased spacing

limbs/digits/tail

long humerus ( J:142946 )

• 24% longer than controls

long ulna ( J:142946 )

• 9% longer than controls

long femur ( J:142946 )

• 21% longer than controls

long tibia ( J:142946 )

• 14% longer than controls

long limbs ( J:142946 )

• longer than controls

abnormal tail morphology ( J:142946 )

long tail ( J:142946 )

• relative to controls

• continues growing past 5 months of age rather than stopping at 3 months

kinked tail ( J:142946 )

• 57% of tails with kinks or bends