Phenotypes associated with this allele

• Allele Symbol: Bptf^{Gt(A012C04)Wrst}
• Allele Name: gene trap A012C04, Wolfgang Wurst
• Allele ID: MGI:3823037
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bptf^Gt(A012C04)Wrst/Bptf^Gt(A012C04)Wrst	either: 129S2/SvPas-Bptf^Gt(A012C04)Wrst or B6.129S2-Bptf^Gt(A012C04)Wrst or (involves: 129S2/SvPas * CD-1)	MGI:3823040

Genotype
MGI:3823040

hm1

• Allelic Composition: Bptf^{Gt(A012C04)Wrst}/Bptf^{Gt(A012C04)Wrst}
• Genetic Background: either: 129S2/SvPas-Bptf^{Gt(A012C04)Wrst} or B6.129S2-Bptf^{Gt(A012C04)Wrst} or (involves: 129S2/SvPas * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142592 )

• significant loss of embryos is seen by E9.5 with no survivors by E11.5

embryo

abnormal developmental patterning ( J:142592 )

abnormal proximal-distal axis patterning ( J:142592 )

• at E6.5 very little elongation along the proximodistal axis is seen

abnormal rostral-caudal axis patterning ( J:142592 )

• at E7.5, markers of anterior or posterior tissue are absent

• at E8.5, embryos lack most structures that reflect rostral-caudal patterning

embryonic growth arrest ( J:142592 )

• appear to arrest between E5.5 and E6.5

embryonic growth retardation ( J:142592 )

• progressive growth retardation

decreased embryo size ( J:142592 )

• substantially smaller than littermates at E5.5 - 6.5

thick embryonic epiblast ( J:142592 )

• at E7.5 the embryonic ectoderm tends to be irregularly thick

abnormal egg cylinder morphology ( J:142592 )

• at E7.5 the egg cylinder has a hook like shape

abnormal primitive streak formation ( J:142592 )

• no defined primitive streak can be recognized at E7.5

abnormal primitive streak elongation ( J:142592 )

• the primitive streak fails to extend correctly

abnormal extraembryonic tissue morphology ( J:142592 )

• substantial reduction in extraembryonic tissue at the proximal pole at E6.5

small ectoplacental cone ( J:142592 )

• at E6.5 the ectoplacental cone is barely detectable

• at E7.5 the ectoplacental cone is smaller and only partly contacts the adjacent decidua

abnormal chorion morphology ( J:142592 )

• chorion development is strongly reduced or absent

absent chorion ( J:142592 )

• chorion may be absent

abnormal visceral endoderm morphology ( J:142592 )

• at E7.5 the visceral endoderm tends to be irregularly thick

growth/size/body

embryonic growth retardation ( J:142592 )

• progressive growth retardation

decreased embryo size ( J:142592 )

• substantially smaller than littermates at E5.5 - 6.5