All Phenotypes Htr2c<tm1Knk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr2c^tm1Knk/Htr2c^tm1Knk	B6.Cg-Htr2c^tm1Knk	MGI:3823071
hm2	Htr2c^tm1Knk/Htr2c^tm1Knk	C.Cg-Htr2c^tm1Knk	MGI:3823070
ht3	Htr2c^tm1Knk/Htr2c⁺	B6.Cg-Htr2c^tm1Knk	MGI:3823076
ht4	Htr2c^tm1Knk/Htr2c^tm2Knk	B6.Cg-Htr2c^tm1Knk/Htr2c^tm2Knk	MGI:3823077
cx5	Htr2c^tm1Knk/Y Mc4r^tm1Lowl/Mc4r^tm1Lowl	involves: 129S4/SvJae * C57BL/6	MGI:3823073
ot6	Htr2c^tm1Knk/Y	B6.Cg-Htr2c^tm1Knk	MGI:3823072
ot7	Htr2c^tm1Knk/Y	C.Cg-Htr2c^tm1Knk	MGI:3823069

Allelic Composition	Htr2c^tm1Knk/Htr2c^tm1Knk
Genetic Background	B6.Cg-Htr2c^tm1Knk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2c^tm1Knk mutation (1 available); any Htr2c mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:142503 )

• less than 20% of mice survive the postnatal period

• however, removal of competing wild-type and female heterozygous littermates increases survival to 80%

growth/size/body

decreased body mass index ( J:142503 )

decreased body weight ( J:142503 )

slow postnatal weight gain ( J:142503 )

• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers

• however, between 3 and 5 weeks of age growth rates are normal

decreased body length ( J:142503 )

• mice exhibit decreased body length compared to wild-type mice but this difference becomes less significant after weaning

Allelic Composition	Htr2c^tm1Knk/Htr2c^tm1Knk
Genetic Background	C.Cg-Htr2c^tm1Knk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2c^tm1Knk mutation (1 available); any Htr2c mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:142503 )

• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers

Allelic Composition	Htr2c^tm1Knk/Htr2c⁺
Genetic Background	B6.Cg-Htr2c^tm1Knk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2c^tm1Knk mutation (1 available); any Htr2c mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:142503 )

Allelic Composition	Htr2c^tm1Knk/Htr2c^tm2Knk
Genetic Background	B6.Cg-Htr2c^tm1Knk/Htr2c^tm2Knk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2c^tm1Knk mutation (1 available); any Htr2c mutation (13 available)
Htr2c^tm2Knk mutation (1 available); any Htr2c mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:142503 )

Allelic Composition	Htr2c^tm1Knk/Y Mc4r^tm1Lowl/Mc4r^tm1Lowl
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2c^tm1Knk mutation (1 available); any Htr2c mutation (13 available)
Mc4r^tm1Lowl mutation (2 available); any Mc4r mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

polyphagia ( J:142503 )

• mice exhibit hyperphagia

growth/size/body

growth/size/body region phenotype ( J:142503 )

N	• unlike when either gene is knocked-out, mice exhibit normal growth rates

decreased body mass index ( J:142503 )

• at 6 weeks but not 16 weeks

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:142503 )

• mice exhibit convulsions and death at a dose of MK212 (a HTR2C-selective agonist) that is 100 times lower than in wild-type mice

postnatal lethality, incomplete penetrance ( J:142503 )

• less than 20% of mice survive the postnatal period

• however, removal of competing wild-type and female heterozygous littermates increases survival to 80%

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:142503 )

N	• despite decreased growth, mice exhibit normal levels of thyroxine and corticosterone

decreased circulating glucose level ( J:142503 )

• at 3 weeks but not 6 weeks

increased circulating ghrelin level ( J:142503 )

• at 3 weeks, circulating ghrelin levels are higher than in wild-type mice

• however, by 6 weeks circulating ghrelin levels are normal

decreased circulating insulin level ( J:142503 )

• at 3 and 6 weeks

decreased circulating insulin-like growth factor I level ( J:142503 )

decreased circulating leptin level ( J:142503 )

• at 3 weeks, circulating leptin levels are lower than in wild-type mice

• however, leptin levels are normal at 6 weeks

increased circulating growth hormone level ( J:142503 )

decreased circulating cholesterol level ( J:142503 )

decreased circulating triglyceride level ( J:142503 )

abnormal body temperature ( J:142503 )

• mice exhibit more prominent hypothermia than wild-type mice in response to 8-OH-DPAT (a HTR1A-specific agonist)

• however, untreated mice exhibit normal body temperature

abnormal metabolism ( J:142503 )

• unlike in wild-type mice, metabolic rate is not increased by treatment with CL316243 (a beta-adrenergic-specific agonist)

increased basal metabolism ( J:142503 )

• mice exhibit a 40% increase in basal metabolic rate compared to in wild-type mice

• treatment with SB242084 reduces energy expenditure but it remains higher than in wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:142503 )

• mice exhibit convulsions and death at a dose of MK212 (a HTR2C-selective agonist) that is 100 times lower than in wild-type mice

increased physiological sensitivity to xenobiotic ( J:142503 )

• mice exhibit more prominent hypothermia than wild-type mice in response to 8-OH-DPAT (a HTR1A-specific agonist)

• mice exhibit convulsions and death at a dose of MK212 (a HTR2C-selective agonist) that is 100 times lower than in wild-type mice

• mice exhibit increased sensitivity to mCPP and Ro60-0174, HTR2C-selective agonists

growth/size/body

decreased body fat mass ( J:142503 )

• adipose accumulation is lower than in wild-type mice

decreased body mass index ( J:142503 )

decreased body weight ( J:142503 )

decreased body length ( J:142503 )

• mice exhibit decreased body length compared to wild-type mice but this difference becomes less significant after weaning

postnatal growth retardation ( J:142503 )

• postnatal growth retardation is not rescued by injection of growth hormone

slow postnatal weight gain ( J:142503 )

• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers

• however, between 3 and 5 weeks of age growth rates are normal

behavior/neurological

enhanced behavioral response to xenobiotic ( J:142503 )

• low doses of MK212 result in more pronounced hypoactivity than in wild-type mice, and food intake can be decreased by treatment with MK212 or mCPP

• low doses of SB242084, but not ketanserin or SB204741 (all HTR2C-specific antagonists) induce more hypolocomotion than in wild-type mice that cannot be reverted by treatment with haloperidol (a D2, D3 and D4 dopamine receptor antagonist) or R(+)-SCH23390 (a D1 dopamine receptor antagonist)

polyphagia ( J:142503 )

• mice exhibit hyperphagia

• however, food intake can be decreased by treatment with MK212

decreased locomotor activity ( J:142503 )

• mice are 2-fold less active than wild-type mice

adipose tissue

decreased white adipose tissue amount ( J:142503 )

decreased body fat mass ( J:142503 )

• adipose accumulation is lower than in wild-type mice

decreased brown adipose tissue mass ( J:142503 )

Allelic Composition	Htr2c^tm1Knk/Y
Genetic Background	C.Cg-Htr2c^tm1Knk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2c^tm1Knk mutation (1 available); any Htr2c mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

slow postnatal weight gain ( J:142503 )

• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers

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