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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(GATA6-cre)#Jbeb
transgene insertion #, John B E Burch
MGI:3823206
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(GATA6-cre)#Jbeb/0
involves: 129 * C57BL/6 MGI:5538606
cn2
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(GATA6-cre)#Jbeb/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB MGI:3663711


Genotype
MGI:5538606
cn1
Allelic
Composition
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(GATA6-cre)#Jbeb/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (49 available)
Tg(GATA6-cre)#Jbeb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in most mice from E12.5 to E13.5




Genotype
MGI:3663711
cn2
Allelic
Composition
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(GATA6-cre)#Jbeb/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Bmpr1atm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(GATA6-cre)#Jbeb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 45% of 3-month old mutants show longer mitral septal leaflets
• exhibit a premature disappearance of the myocardial layer in the tricuspid mural leaflet (present at E14.5 but absent at E15.5)
• the posterior annulus fibrosis is displaced downward into the right ventricular cavity in one of six mutants
• 36% of 3-month old mutants show longer tricuspid mural leaflets than control valves
• 3-month old mutants show significantly decreased left ventricular (LV) ejection fraction and increased LV-end-systolic dimension and LV-end-diastolic dimension
• show a 2-fold increase in left atrial pressure consistent with mitral insufficiency
• isolated Langendorff perfused mutant hearts show a delta wave with abnormal surface ECG
• hearts with abnormal surface ECG show a base-to-apex activation pattern with evidence of a posterior paraseptal bypass tract
• the annulus fibrosus is disrupted resulting in ventricular preexcitation
• 6 of 33 mutants, aged between 2 and 6 months, show absence of PR interval

muscle
• 3-month old mutants show significantly decreased left ventricular (LV) ejection fraction and increased LV-end-systolic dimension and LV-end-diastolic dimension





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory