Analysis Tools
mortality/aging
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• mice die by week 2 to 3 of age
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• at 2 weeks of age, mice exhibit signs of premature aging such as an unstable gait, cachexia, osteopenia with kyphosis and a profound decrease in fat deposition compared to wild-type mice
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skeleton
| N |
• unlike mice homozygous for a null allele, tooth eruption occurs
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• narrower than in wild-type mice
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• mice exhibit small growth plates with decreased epiphyseal volumes compared to in wild-type mice
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• at 2 weeks of age
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• at E18.5
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• at 2 weeks, mice exhibit decreases in trabecular and cortical bone volume, and trabecular number and thickness with an increase in trabecular space compared to in wild-type mice
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osteoporosis
(
J:142669
)
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• as determined by decreased bone mineral density
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• chondrocyte numbers are decreased due to decreased proliferation compared to in wild-type mice
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growth/size/body
| N |
• unlike mice homozygous for a null allele, mice exhibit normal limb length
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• slightly at birth
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• by P3 mice, fail to grow relative to wild-type mice
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cellular
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• fed mice exhibit increased autophagy compared to in wild-type mice but not as high as in starved wild-type mice
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• apoptosis in the spleen and thymus is increased compared to in wild-type mice
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• at E18.5, proliferation of cells in the subventricular zone and hippocampus are decreased compared to in wild-type mice
• at P14, cell proliferation in the bone marrow is decreased compared to in wild-type mice
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cardiovascular system
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• large blood vessels are atrophic
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nervous system
adipose tissue
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• at 2 weeks of age, mice exhibit a profound decrease in fat deposition compared to wild-type mice
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behavior/neurological
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• at 2 weeks of age, mice exhibit unstable gait
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homeostasis/metabolism
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• fed mice exhibit increased autophagy compared to in wild-type mice but not as high as in starved wild-type mice
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hematopoietic system
immune system
integument
