Phenotypes associated with this allele

• Allele Symbol: Aurka^{Gt(XQ0149)Wtsi}
• Allele Name: gene trap XQ0149, Wellcome Trust Sanger Institute
• Allele ID: MGI:3826513
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aurka^Gt(XQ0149)Wtsi/Aurka^Gt(XQ0149)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:4456486
ht2	Aurka^Gt(XQ0149)Wtsi/Aurka^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4456487

Genotype
MGI:4456486

hm1

• Allelic Composition: Aurka^{Gt(XQ0149)Wtsi}/Aurka^{Gt(XQ0149)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation ( J:143099 )

embryo

embryonic growth arrest ( J:143099 )

• at E3.5 homozygous embryos contain only 8 to 16 cells and these embryos fail to develop further when cultured suggesting growth arrest occurs at or before the 16 cell stage

cellular

abnormal mitosis ( J:143099 )

• at E3.5 none of the cells in the embryo stain positive for a mitotic marker and none of the cells contain any assembled spindles

abnormal mitotic spindle morphology ( J:143099 )

• at E3.5 none of the cells contain any assembled spindles

Genotype
MGI:4456487

ht2

• Allelic Composition: Aurka^{Gt(XQ0149)Wtsi}/Aurka⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased tumor incidence ( J:143099 )

• frequency of tumors is 25.5% compared to 8.8% in controls

• tumors are found in various organs including the thymus, liver, lung and lymph nodes

increased hepatoma incidence ( J:143099 )

• seen in one mouse

increased lymphoma incidence ( J:143099 )

• most tumors are lymphomas that invade the lung

increased lung carcinoma incidence ( J:143099 )

• seen in 5 cases

increased squamous cell carcinoma incidence ( J:143099 )

• seen in one mouse

cellular

aneuploidy ( J:143099 )

• increase in the percentage of MEFs displaying aneuploidy compared to controls

chromosomal instability ( J:143099 )

• MEFS have about 70% more cells containing greater than 4N content

liver/biliary system

increased hepatoma incidence ( J:143099 )

• seen in one mouse

respiratory system

increased lung carcinoma incidence ( J:143099 )

• seen in 5 cases