Phenotypes associated with this allele

• Allele Symbol: Mirc55^tm1.1Cjku
• Allele Name: targeted mutation 1.1, Calvin J Kuo
• Allele ID: MGI:3826824
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc55^tm1.1Cjku/Mirc55^tm1.1Cjku	involves: 129/Sv * 129S1/Sv * C57BL/6	MGI:3826830

Genotype
MGI:3826830

hm1

• Allelic Composition: Mirc55^tm1.1Cjku/Mirc55^tm1.1Cjku
• Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:143206 )

• mice begin to die at E14.5 and 50% do not survive to birth

cardiovascular system

decreased angiogenesis ( J:143206 )

• mice exhibit decreased postnatal retinal angiogenesis consisting of compromised radial migration, a 40% decrease in the area of vascularization and abnormally thickened endothelial sprouts

• cranial angiogenesis is delayed compared to in wild-type mice

• in a VEGF-dependent corneal micropocket assay, mice exhibit a 50% impairment in angiogenesis compared to wild-type corneas

hemorrhage ( J:143206 )

• at E15.5, 20% of mice exhibit hemorrhaging from ruptured blood vessels, most prominently in the jugular and subcutaneous regions

homeostasis/metabolism

skin edema ( J:143206 )

• at E14.5

integument

skin edema ( J:143206 )

• at E14.5