Phenotypes associated with this allele

• Allele Symbol: Dnm3os^tm1Tkk
• Allele Name: targeted mutation 1, Takashi Nakaoka
• Allele ID: MGI:3826836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnm3os^tm1Tkk/Dnm3os^tm1Tkk	involves: 129 * C57BL/6 * ICR	MGI:3826842

Genotype
MGI:3826842

hm1

• Allelic Composition: Dnm3os^tm1Tkk/Dnm3os^tm1Tkk
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:143209 )

• although most mice die prior to weaning some survive into adulthood and reproduce

postnatal lethality, incomplete penetrance ( J:143209 )

• most mice die between P7 and P30

• however, survival until weaning can be improved by reduced littermate competition and the few mice that survive into adulthood reproduce

skeleton

abnormal cranium morphology ( J:143209 )

• mice exhibit cranial deformity

abnormal neurocranium morphology ( J:143209 )

• at P14, the calvarium is shortened in the naso-occipital length compared to in wild-type mice

malocclusion ( J:143209 )

• some mice exhibit bite overclosure

abnormal vertebrae morphology ( J:143209 )

• at E18, dorsal vertebrae are hypoplastic

• at E18, cervical and thoracic vertebrae exhibit impaired ossification and elongation compared to in wild-type mice

abnormal thoracic vertebrae morphology ( J:143209 )

• adult mice exhibit loss of spinous processes on thoracic vertebrae

fusion of vertebral arches ( J:143209 )

• at P14, neural arches of cervical vertebrae exhibit fusion along the midline

decreased bone mineral density ( J:143209 )

• mice exhibit osteopenia in the long bones at P60

decreased bone mineral density of vertebrae ( J:143209 )

• mice exhibit osteopenia in the vertebrae by P150

abnormal bone ossification ( J:143209 )

• at E18, cervical and thoracic vertebrae exhibit impaired ossification and elongation compared to in wild-type mice

growth/size/body

malocclusion ( J:143209 )

• some mice exhibit bite overclosure

slow postnatal weight gain ( J:143209 )

decreased body height ( J:143209 )

• mice exhibit shortened stature compared to wild-type mice

decreased body length ( J:143209 )

• mice are slightly shorter than wild-type just before birth

decreased fetal weight ( J:143209 )

• fetal weight is less than wild-type before birth

behavior/neurological

abnormal gait ( J:143209 )

• some mice exhibit an unsteady gait particularly involving the hindlimbs

paresis ( J:143209 )

• in some mice

adipose tissue

abnormal epididymal fat pad morphology ( J:143209 )

• smaller than in wild-type mice

muscle

abnormal muscle morphology ( J:143209 )

• the muscle bundle of the back at the cervical level are smaller than in wild-type mice

craniofacial

abnormal cranium morphology ( J:143209 )

• mice exhibit cranial deformity

abnormal neurocranium morphology ( J:143209 )

• at P14, the calvarium is shortened in the naso-occipital length compared to in wild-type mice

malocclusion ( J:143209 )

• some mice exhibit bite overclosure