About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arg1tm1Pmu
targeted mutation 1, Peter J Murray
MGI:3826847
Summary 2 genotypes


Genotype
MGI:3826860
cn1
Allelic
Composition		 Arg1tm1Pmu/Arg1tm1Pmu
Lyz2tm1(cre)Ifo/?
Genetic
Background		 B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Pmu mutation (2 available); any Arg1 mutation (28 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to parasitic infection ( J:143229 )
• mice are resistant to the wasting disease caused by systemic infection with T. gondii
• control mice lose 20% of their body weight by 40 days after T. gondii infection while infected mutant mice have no loss of body weight




Genotype
MGI:3826863
cn2
Allelic
Composition		 Arg1tm1Pmu/Arg1tm1Pmu
Tg(Tek-cre)1Ywa/?
Genetic
Background		 B6.Cg-Tg(Tek-cre)1Ywa Arg1tm1Pmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Pmu mutation (2 available); any Arg1 mutation (28 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:143229 )
• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity
increased macrophage nitric oxide production ( J:143229 )
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection
decreased susceptibility to bacterial infection ( J:143229 )
• mice infected with M. tuberculosis have lower bacterial counts than wild-type littermates in the lungs after the initial bacterial growth period
• there is also lower bacterial load in the spleens of the mice 70 days after infection with M. tuberculosis
• lung granulomas in these infected mice occupy a smaller fraction of the total lung area and have a more pronounced lymphocytic infiltrate

homeostasis/metabolism
abnormal nitric oxide homeostasis ( J:143229 )
• there is more NO activity in liver granulomas of mice infected with M. tuberculosis
increased macrophage nitric oxide production ( J:143229 )
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection

hematopoietic system
abnormal macrophage physiology ( J:143229 )
• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity
increased macrophage nitric oxide production ( J:143229 )
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory