cardiovascular system
• at E12.5, the relative volume of abnormal heart tissue begins to decline to 42% in ventricles and 47% in atria and is further reduced at E16.5 to 18% in ventricles and 19% in the atria then 10% in ventricles and 17% in the atria prior to birth
• at E12.5 and E13.5, cardiomyocytes appear small and round compared to wild-type cells
• however, the absolute volume of heart tissue before birth is unchanged
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• cardiomyocytes appear smaller at E12.5 and E13.5
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• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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muscle
• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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cellular
• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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