mortality/aging
• 80% of homozygous mice from homozygous females die between E14.5 and E16.5
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• half as many mice as expected are alive at weaning
• no homozygous mice from homozygous females survive to weaning
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cellular
• in homozygous mutant embryos derived from a null females
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• 80% of homozygous mice from homozygous females die between E14.5 and E16.5
• no homozygous mice from homozygous females survive to weaning
• imprinting is abnormal in homozygous mutant embryos derived from a null females
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