Phenotypes associated with this allele

• Allele Symbol: Dusp6^tm1Jmol
• Allele Name: targeted mutation 1, Jeffery D Molkentin
• Allele ID: MGI:3827011
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp6^tm1Jmol/Dusp6^tm1Jmol	involves: 129 * C57BL/6	MGI:3827012

Genotype
MGI:3827012

hm1

• Allelic Composition: Dusp6^tm1Jmol/Dusp6^tm1Jmol
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased satellite cell numbers in Dusp6^tm1Jmol/Dusp6^tm1Jmol regenerating muscle following injury

cardiovascular system

cardiovascular system phenotype ( J:142966 )

N • despite the increase in heart size, cardiac function at 1 year of age is similar to controls

abnormal heart development ( J:142966 )

• at E13.5 a 30% increase in BrdU incorporation is seen in hearts

increased heart weight ( J:142966 )

• increased heart weight relative to body weight compared to controls

heart hyperplasia ( J:142966 )

• analysis suggests increased heart size is due to increased cellularity not an increase in cell size

decreased response of heart to induced stress ( J:142966 )

• myocyte hypertrophy in response to transverse aortic constriction is reduced compared to controls

• results from long term transverse aortic constriction suggest homozygotes are partially protected from long term pressure overload induced dysfunction

• reduced decompensation at 4 weeks after permanent ligation of the left coronary artery

decreased myocardial infarct size ( J:142966 )

• following permanent ligation of the left coronary artery the degree of infarct expansion is reduced compared to controls

cellular

decreased sensitivity to induced cell death ( J:142966 )

• reduced susceptibility to staurosporine induced apoptosis

hematopoietic system

increased spleen weight ( J:142966 )

• increased spleen weight relative to body weight compared to controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:142966 )

• myocyte hypertrophy in response to transverse aortic constriction is reduced compared to controls

• results from long term transverse aortic constriction suggest homozygotes are partially protected from long term pressure overload induced dysfunction

• reduced decompensation at 4 weeks after permanent ligation of the left coronary artery

decreased myocardial infarct size ( J:142966 )

• following permanent ligation of the left coronary artery the degree of infarct expansion is reduced compared to controls

immune system

increased spleen weight ( J:142966 )

• increased spleen weight relative to body weight compared to controls

muscle

muscle phenotype ( J:190460 )

N • at 2 months, untreated mice exhibit normal skeletal muscle tissue morphology

increased satellite cell number ( J:190460 )

• moderate in untreated mice

• 2.4-fold increase in self-renewed satellite cells following cardiotoxin treatment

• 2-fold increase in quiescent sublaminar Pax7+ satellite cells following cardiotoxin treatment

• however, the number of quiescent sublaminar Pax7+ satellite cells is number in untreated mice

abnormal muscle physiology ( J:190460 )

• at 2 months, satellite cells exhibit impaired ability to return to quiescence compared with control cells

growth/size/body

increased heart weight ( J:142966 )

• increased heart weight relative to body weight compared to controls

heart hyperplasia ( J:142966 )

• analysis suggests increased heart size is due to increased cellularity not an increase in cell size

increased spleen weight ( J:142966 )

• increased spleen weight relative to body weight compared to controls