All Phenotypes Glp2r<tm1Ddr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glp2r^tm1Ddr/Glp2r^tm1Ddr	involves: C57BL/6	MGI:5319216
cx2	Apc^Min/Apc⁺ Glp2r^tm1Ddr/Glp2r⁺	involves: C57BL/6J	MGI:3827117
cx3	Apc^Min/Apc⁺ Glp2r^tm1Ddr/Glp2r^tm1Ddr	involves: C57BL/6J	MGI:3827123

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:182545 )

• increase in the proportion of moribund mice following indomethacin induced small bowel enteritis

digestive/alimentary system

digestive/alimentary phenotype ( J:182545 )

N	• intestinal morphology is similar to wild-type controls in nonstressed mice and in mice treated with dextran sulfate

abnormal feces composition ( J:182545 )

• significant reductions in the proportions of Firmicutes and Actinobacteria and a significant increase in Bacteroidetes and Clostridiales in the feces

abnormal digestive system physiology ( J:182545 )

• sustained h[Gly2]-GLP-2 (glucagon like peptide 2) administration fails to elicit an intestinotrophic response unlike in wild-type controls

abnormal intestine physiology ( J:182545 )

• increase in small intestinal sensitivity to indomethacin or irinotecan toxicity

• increased small bowel bacterial load

abnormal Paneth cell physiology ( J:182545 )

• expression analysis indicates defects in Paneth cell regulated host-bacteria interactions and cultured Paneth cells show reduced bactericidal activity after stimulation with carbamylcholine and LPS

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:182545 )

• increase in the proportion of moribund mice following indomethacin induced small bowel enteritis

increased physiological sensitivity to xenobiotic ( J:182545 )

• more mice show signs of bacterial infection after indomethacin treatment

• irinotecan treatment induces a significant decrease in jejunal crypt density and depth in contrast to controls where only crypt depth is decreased

• systemic bacteremia is seen after irinotecan treatment

Allelic Composition	Apc^Min/Apc⁺ Glp2r^tm1Ddr/Glp2r⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (157 available)
Glp2r^tm1Ddr mutation (0 available); any Glp2r mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:141821 )

• number similar to situation in Apc^Min heterozygous mice

abnormal tumor morphology ( J:141821 )

• size similar to situation in Apc^Min heterozygous mice

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:141821 )

• villus height is similar to Apc^Min heterozygotes

abnormal crypts of Lieberkuhn morphology ( J:141821 )

• crypt morphology is similar to Apc^Min heterozygotes

increased intestinal adenoma incidence ( J:141821 )

• number similar to situation in Apc^Min heterozygous mice

intestine polyps ( J:141821 )

• number similar to situation in Apc^Min heterozygous mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:141821 )

• crypt morphology is similar to Apc^Min heterozygotes

Allelic Composition	Apc^Min/Apc⁺ Glp2r^tm1Ddr/Glp2r^tm1Ddr
Genetic Background	involves: C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:141821 )

• villus height is similar to Apc^Min heterozygotes

abnormal crypts of Lieberkuhn morphology ( J:141821 )

• crypt morphology is similar to Apc^Min heterozygotes

increased intestinal adenoma incidence ( J:141821 )

• number similar to situation in Apc^Min heterozygous mice

intestine polyps ( J:141821 )

• number similar to situation in Apc^Min heterozygous mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:141821 )

• crypt morphology is similar to Apc^Min heterozygotes

neoplasm

increased intestinal adenoma incidence ( J:141821 )

• number similar to situation in Apc^Min heterozygous mice

abnormal tumor morphology ( J:141821 )

• size similar to situation in Apc^Min heterozygous mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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