All Phenotypes Dock5<Gt(AN0268)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dock5^{Gt(AN0268)Wtsi}
gene trap AN0268, Wellcome Trust Sanger Institute
MGI:3828069

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi}	involves: 129P2/OlaHsd * C57BL/6	MGI:3828077
cx2	Dock1^tm1Jfco/Dock1^tm1Jfco Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi}	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3828078
cx3	Dock1^tm1Jfco/Dock1⁺ Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi}	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3828079
cx4	Dock1^tm1Jfco/Dock1⁺ Dock5^{Gt(AN0268)Wtsi}/Dock5⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3828080

Allelic Composition	Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock5^{Gt(AN0268)Wtsi} mutation (1 available); any Dock5 mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:143342 )

N	• mice exhibit normal life-span

muscle

muscle phenotype ( J:143342 )

N	• mice exhibit normal muscle development and morphology

Allelic Composition	Dock1^tm1Jfco/Dock1^tm1Jfco Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi}
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1^tm1Jfco mutation (0 available); any Dock1 mutation (130 available)
Dock5^{Gt(AN0268)Wtsi} mutation (1 available); any Dock5 mutation (158 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:143342 )

• no mice are present at E14.5

embryo

abnormal embryo development ( J:143342 )

• mice fail to undergo early embryogenesis and instead undergo necrosis

Allelic Composition	Dock1^tm1Jfco/Dock1⁺ Dock5^{Gt(AN0268)Wtsi}/Dock5^{Gt(AN0268)Wtsi}
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased skeletal muscle fiber diameter ( J:143342 )

• mice exhibit variably thin myofibrils

Allelic Composition	Dock1^tm1Jfco/Dock1⁺ Dock5^{Gt(AN0268)Wtsi}/Dock5⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:143342 )

N	• intercostal muscles develop normally

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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