vision/eye
• at 5 months, the lens exhibits breakdown of the cortex caused by enlarged and increased vacuoles
• at 12 months, the lens collapses without rupture
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• at 5 to 8 weeks, mice display vacuoles in the whole lens
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• at 5 to 8 weeks, lens fibers are irregularly distributed unlike in wild-type mice
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• mice develop cataracts by week 5 that begins as a small irregular opacity and spreads to the entire lens by adulthood
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