immune system
• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4tm1Frad homozygous control mice
• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice
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• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4tm1Frad homozygous control mice
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• the absolute numbers of immature B cells in the thymus are increased 340-fold compared to in Dll4tm1Frad homozygous control mice
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• T cells differentiated in the thymus is nearly completely blocked unlike in Dll4tm1Frad homozygous control mice
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• flow cytometry indicates a near complete loss of double positive T cells in the thymus
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• flow cytometry indicates a near complete loss of CD4+ T cells in the thymus
• absolute numbers of CD4+ T cells is reduced 180- to 3000-fold compared to Dll4tm1Frad homozygous in control mice
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• flow cytometry indicates a near complete loss of CD8+ T cells in the thymus
• absolute numbers of CD8+ T cells is reduced 180- to 3000-fold compared to in Dll4tm1Frad homozygous control mice
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hematopoietic system
• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4tm1Frad homozygous control mice
• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice
|
• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4tm1Frad homozygous control mice
|
• the absolute numbers of immature B cells in the thymus are increased 340-fold compared to in Dll4tm1Frad homozygous control mice
|
• T cells differentiated in the thymus is nearly completely blocked unlike in Dll4tm1Frad homozygous control mice
|
• flow cytometry indicates a near complete loss of double positive T cells in the thymus
|
• flow cytometry indicates a near complete loss of CD4+ T cells in the thymus
• absolute numbers of CD4+ T cells is reduced 180- to 3000-fold compared to Dll4tm1Frad homozygous in control mice
|
• flow cytometry indicates a near complete loss of CD8+ T cells in the thymus
• absolute numbers of CD8+ T cells is reduced 180- to 3000-fold compared to in Dll4tm1Frad homozygous control mice
|
endocrine/exocrine glands
• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4tm1Frad homozygous control mice
• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice
|
• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4tm1Frad homozygous control mice
|