Phenotypes associated with this allele

• Allele Symbol: Olig3^tm1Qiu
• Allele Name: targeted mutation 1, Mengsheng Qiu
• Allele ID: MGI:3828309
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Olig3^tm1Qiu/Olig3^tm1Qiu	Not Specified	MGI:3828337

Genotype
MGI:3828337

hm1

• Allelic Composition: Olig3^tm1Qiu/Olig3^tm1Qiu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:143462 )

• mice die soon after birth due to respiratory failure

nervous system

abnormal neuron differentiation ( J:143462 )

• at E10.5, the cell fate specification of dorsal progenitor 1 through 3 domains of neural progenitor cells is altered such that Pou4f1 (Brn3a)+ dorsal interneuron 2 and dorsal interneuron 3 neurons are respecified to Pax2+ dorsal interneuron 4 neurons

• at E18.5, Phox2b+ neurons derived from the caudal rhombic lip of dorsal progenitor 3 domain is inhibited and the formation of brainstem (nor) adrenergic centers and first-order relay visceral sensory neuron is disrupted as determined by marker expression

abnormal rostral migratory stream morphology ( J:143462 )

• expression of Zic1 in the extramural migratory stream is decreased compared to in wild-type mice

• expression of Pou4f1 (Brn3a) in the intramural migratory stream is lost

abnormal inferior olivary complex morphology ( J:143462 )

• at E14.5 through E18.5, Pou4f1 (Brn3a)+ climbing fibers are not detected in the inferior olive nucleus unlike in wild-type mice indicating a loss of these neurons

• at E18.5, Nissl staining fails to detect the inferior olivary complex structure

• however, no ectopic climbing fibers or inferior olivary complexes are detected

abnormal hippocampal mossy fiber morphology ( J:143462 )

• at E14.5 and E16.5, formation of the mossy fiber nuclei is inhibited unlike in wild-type mice as determined by expression of Barhl1 and Zic1

• unlike in wild-type mice, lateral reticular nuclei mossy fiber neurons are not detected

respiratory system

respiratory failure ( J:143462 )

homeostasis/metabolism

cyanosis ( J:143462 )

cellular

abnormal neuron differentiation ( J:143462 )

• at E10.5, the cell fate specification of dorsal progenitor 1 through 3 domains of neural progenitor cells is altered such that Pou4f1 (Brn3a)+ dorsal interneuron 2 and dorsal interneuron 3 neurons are respecified to Pax2+ dorsal interneuron 4 neurons

• at E18.5, Phox2b+ neurons derived from the caudal rhombic lip of dorsal progenitor 3 domain is inhibited and the formation of brainstem (nor) adrenergic centers and first-order relay visceral sensory neuron is disrupted as determined by marker expression