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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dll4tm1Kaho
targeted mutation 1, Katsuto Hozumi
MGI:3828459
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dll4tm1Kaho/Dll4tm1Kaho
Tg(Foxn1-cre)8Ghr/0
involves: C57BL/6 * DBA/2 MGI:3828486


Genotype
MGI:3828486
cn1
Allelic
Composition
Dll4tm1Kaho/Dll4tm1Kaho
Tg(Foxn1-cre)8Ghr/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm1Kaho mutation (0 available); any Dll4 mutation (27 available)
Tg(Foxn1-cre)8Ghr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus contains one third to one twenty-fifth the number of cells as in Dll4tm1Kaho homozygous controls
• double negative 1 (DN1) cells present in the thymus do not develop into T cells but instead differentiate into immature B cell phenotype
• however, differentiation of wild-type hematopoietic progenitor cells transfected with an active form of Notch1 occurs when they are co-culture of thymic lobes lacking Dll4 expression
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls

hematopoietic system
• the thymus contains one third to one twenty-fifth the number of cells as in Dll4tm1Kaho homozygous controls
• double negative 1 (DN1) cells present in the thymus do not develop into T cells but instead differentiate into immature B cell phenotype
• however, differentiation of wild-type hematopoietic progenitor cells transfected with an active form of Notch1 occurs when they are co-culture of thymic lobes lacking Dll4 expression
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls

endocrine/exocrine glands
• the thymus contains one third to one twenty-fifth the number of cells as in Dll4tm1Kaho homozygous controls





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory